PhD Scientific Days 2022

Clinical Medicine VI. (Poster discussion will take place on the terrace of the room during the Coffee Break)

The impact of right ventricular trabeculation on right ventricular function in patients with left ventricular noncompaction

Előadó neve

Dr. Kiss, Anna Réka

Előadó munkahelye

Heart and Vascular Center of Semmelweis University

Előadó telefonszáma

+36208258102

Előadó e-mail címe

annarekak@gmail.com

Az előadás címe

The impact of right ventricular trabeculation on right ventricular function in patients with left ventricular noncompaction

Szerző(k) neve és munkahelye

Anna Réka Kiss1, Zsófia Gregor1, Adrián Popovics1, Kinga Grebur1, Liliána Erzsébet Szabó1, Zsófia Dohy1, Attila Kovács1, Bálint Károly Lakatos1, Béla Merkely1, Hajnalka Vágó1, Andrea Szűcs1
1 Heart and Vascular Center of Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Clinical Medicine VI. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Right ventricular (RV) involvement in left ventricular (LV) noncompaction (LVNC) remains unknown. We aimed to describe the RV volumetric, functional, and strain characteristics and clinical features of patients with LVNC and good LV ejection fraction (EF) using cardiac magnetic resonance, to characterize RV trabeculation in LVNC, to study the relationship between RV and LV trabeculation and RV volume and function, and to describe the connection between clinical features and RV trabeculation. 
This retrospective study included 100 Caucasian patients with LVNC and good LV-EF and 100 age- and sex-matched healthy controls. Patients were further divided into two subgroups by the amount of RV indexed trabecular mass (RV-TMi; patients with RV hypertrabeculation (RV-HT) vs. patients with normal amount of RV trabeculation (RV-NT)). We measured the LV and RV volumetric, functional, and TMi values using threshold-based post-processing software and the RV and LV strain values using feature tracking and collected the patients' LVNC-related clinical features. 
Patients had higher RV volumes, lower RV-EF, and worse RV strain values than controls. A total of 22% of patients had higher RV-TMi values than the reference range; furthermore, RV-HT patients had higher RV and LV volumes, lower RV- and LV-EF, and worse RV strain values than RV-NT patients (RV-HT vs. RV-NT; RV-CMi: 17,6±4,5 vs. 14,3±4,2 g/m2; RV-TMi: 29,3±5 vs. 19,2±4,4 g/m2; RV-EF: 59,6±5,2 vs. 63,1±6,2%; RV-GLS: -23,3±2,7 vs. -25,7±4,5%; RV-SS: -13,8±3,4 vs. -17±5%). We identified a strong positive correlation between RV- and LV-TMi and between RV-TMi and RV volumes and a significant inverse relationship between both RV- and LV-TMi and RV function.  The prevalence of LVNC-related clinical features was similar in the RV-HT and RV-NT groups. 
These results suggest that some LVNC patients might have RV noncompaction with subclinical RV dysfunction and without more severe clinical features. 

The research was financed by the Development of Scientific Workshops of Medical, Health Sciences and Pharmaceutical Education (Project identification number: EFOP-3.6.3-VEKOP-16-2017-00009).

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Prof.Dr. Béla Merkely, Dr. Andrea Szűcs

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4147

Start

10:45

End

10:50

Authors (legacy)

Anna Réka Kiss1, Zsófia Gregor1, Adrián Popovics1, Kinga Grebur1, Liliána Erzsébet Szabó1, Zsófia Dohy1, Attila Kovács1, Bálint Károly Lakatos1, Béla Merkely1, Hajnalka Vágó1, Andrea Szűcs1
1 Heart and Vascular Center of Semmelweis University, Budapest, Hungary