PhD Scientific Days 2022

Mental Health Sciences III.

Four-Month-Practice of Autogenic Training Reduced Headache Frequency and Induced Changes in Brain Activation in Response to Fearful and Happy Visual Stimuli in Migraineurs

Előadó neve

Dobos, Dóra, MSc

Előadó munkahelye

Semmelweis University, Department of Pharmacodynamics

Előadó telefonszáma

+36304256112

Előadó e-mail címe

dobos.dora@semmelweis-univ.hu

Az előadás címe

Four-Month-Practice of Autogenic Training Reduced Headache Frequency and Induced Changes in Brain Activation in Response to Fearful and Happy Visual Stimuli in Migraineurs

Szerző(k) neve és munkahelye

Dóra Dobos 1, 2; Edina Szabó 1, 3, 4; Dániel Baksa 1, 2; Kinga Gecse 1, 2; Natália Kocsel 1, 4; Dorottya Pap 1; Terézia Zsombók 1; Lajos R. Kozák 5; Gyöngyi Kökönyei 1, 2, 4; Gabriella Juhász 1, 2, 6, 7
1 SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
2 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest
3 Center for Pain and the Brain (PAIN Research Group), Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA
4 Institute of Psychology, ELTE Eötvös Loránd University, Budapest
5 Magnetic Resonance Research Center, Semmelweis University, Budapest
6 NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
7 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest

Bemutatás módja

Szóbeli

Szekció

Mental Health Sciences III.

Language of the presentation

English

Preferred session

Mental Sciences

Összefoglaló szövege

Introduction: Currently, a significant number of migraine patients cannot take advantage of pharmacotherapy for various reasons. Since stress is a major trigger of migraines, non-pharmacological treatment, such as headache-specific autogenic training (AT), could help patients reduce their headache frequency.
Aims: To evaluate changes in brain activation patterns underlying emotion processing in migraineurs compared to healthy controls, as well as changes in headache frequency in the migraine subsample after regular practice of AT.
Methods: Episodic migraineurs without aura and healthy controls participated in a 16-week long AT, based on the stress-relieving Schultz-type autogenic training and supplemented with psychoeducation, movement therapy and pleasant imagery. Functional magnetic resonance imaging measured subjects’ brain response to emotional faces before and after AT (migraineurs were scanned in the headache-free phase). Also, the migraine frequency was assessed in the migraine group before and after AT.
Results: After the training course, deactivation of the migraine-associated dorsal pons was found in migraineurs using fearful stimuli. Activation changes of the supplementary motor area elicited by fearful faces and insula elicited by happy faces differed significantly in migraineurs compared to healthy controls. Migraine subjects reported significantly fewer headache attacks after AT.
Conclusion: Our results show that the headache-specific autogenic training can contribute to improvements in migraineurs’ clinical parameters and induce neural changes in emotional processing regions that have an important role also in migraine generation and pain modulation. Therefore, AT can be an effective adjuvant to pharmacotherapy of migraine.
Funding: Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002; KTIA_13_NAPA-II/14); National Development Agency (KTIA_NAP_13-1-2013-0001); Hungarian Academy of Sciences, Hungarian National Development Agency, Semmelweis University, and the Hungarian Brain Research Program (KTIA_NAP_13-2-2015-0001) (MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group); the Hungarian Academy of Sciences (MTA-SE Neuropsychopharmacology and Neurochemistry Research Group); 2020-4.1.1.-TKP2020; ÚNKP-20-3-II-SE-51.

University and Doctoral School

Semmelweis University, Doctoral School of Mental Health Sciences

Supervisor

Dr. Juhász Gabriella

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5971

Start

15:30

End

15:45

Authors (legacy)

Dóra Dobos 1, 2; Edina Szabó 1, 3, 4; Dániel Baksa 1, 2; Kinga Gecse 1, 2; Natália Kocsel 1, 4; Dorottya Pap 1; Terézia Zsombók 1; Lajos R. Kozák 5; Gyöngyi Kökönyei 1, 2, 4; Gabriella Juhász 1, 2, 6, 7
1 SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
2 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest
3 Center for Pain and the Brain (PAIN Research Group), Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA
4 Institute of Psychology, ELTE Eötvös Loránd University, Budapest
5 Magnetic Resonance Research Center, Semmelweis University, Budapest
6 NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
7 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest