PhD Scientific Days 2022

Budapest, 6-7 July 2022

Clinical Medicine IV.

Mastoid obliteration decreases the recurrent and the residual disease in cholesteatoma surgery: Systematic review and Meta-analysis of 2077 patients

Előadó neve

Dr. Illés, Kata

Előadó munkahelye

Centre for Translational Medicine, Semmelweis University, Budapest, Hungary

Előadó telefonszáma

308686148

Előadó e-mail címe

i.kataaaa@gmail.com

Az előadás címe

Mastoid obliteration decreases the recurrent and the residual disease in cholesteatoma surgery: Systematic review and Meta-analysis of 2077 patients

Szerző(k) neve és munkahelye

Authors:
Kata Illés MD1,2, Fanni Adél Meznerics MD2,3, Fanni Dembrovszky MD2,4, Péter Fehérvári PhD2,5, András Bánvölgyi MD, PhD2,3, Dezső Csupor PharmD, PhD 2,4,6 Péter Hegyi MD, DSc2,4,7, Tamás Horváth MD, PhD1,2
Affiliations:
1. Department of Otorhinolaryngology, Head and Neck Surgery, Bajcsy-Zsilinszky Hospital, Budapest, Hungary
2. Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
3. Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
4. Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
5. University of Veterinary Medicine, Dept. of Biomathematics and Informatics, Budapest, Hungary
6. Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
7. Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine IV.

Language of the presentation

English

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: Mastoid obliteration in cholesteatoma surgery is getting popular. However, there is a lack of comparative research on this topic, and high-level evidence to prove its effectiveness is missing.
Aim: Our study aims to evaluate the effectiveness of mastoid obliteration compared to the canal wall up (CWU) technique in cholesteatoma surgery based on the systematic review of the literature and the meta-analysis of the data.
Methods: The systematic search was performed in four major databases (MEDLINE, Web of Science, Embase, and CENTRAL) on 14 October 2021. Studies comparing the CWU technique and mastoid obliteration with any kind of material were included. The exclusion criteria were less than 12 months follow-up, patients with congenital cholesteatoma, indefinite description of the surgical method, and animal studies. The protocol was registered on Prospero (registration number: CRD42021282485). The risk of bias was evaluated with the ROBINS-I tool. Data from the eligible studies were collected, and the primary outcomes, residual and recurrent disease rates were analyzed. The secondary outcomes were quality of life, ear discharge, infection rates, hearing results, and the operation time. In the analyses, the random effect model was used. The heterogeneity was identified with I² statistics.
Results: A total of 11 articles with 2077 patients’ data were found eligible; quantitative analyses from 8 articles were completed, as were qualitative analyses from 6 articles. All the identified studies were retrospective cohorts. The odds of residual and recurrent disease were significantly lower in the obliterative group compared to the canal wall up technique (OR=0.45, CI:0.28;0.73, p=0.0012). The qualitative synthesis identified no significant difference in the secondary outcomes, but obliteration elongated the operation time.
Conclusion: Mastoid obliteration could significantly decrease the rate of residual and recurrent cholesteatoma. However, randomized controlled trials are needed to confirm our results.
Funding: The project was not funded.

University and Doctoral School

Semmelweis University, Doctoral School of Pharmaceutical Sciences

Supervisor

Tamás Horváth

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6810

Start

14:45

End

15:00

Authors (legacy)

Authors:
Kata Illés MD1,2, Fanni Adél Meznerics MD2,3, Fanni Dembrovszky MD2,4, Péter Fehérvári PhD2,5, András Bánvölgyi MD, PhD2,3, Dezső Csupor PharmD, PhD 2,4,6 Péter Hegyi MD, DSc2,4,7, Tamás Horváth MD, PhD1,2
Affiliations:
1. Department of Otorhinolaryngology, Head and Neck Surgery, Bajcsy-Zsilinszky Hospital, Budapest, Hungary
2. Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
3. Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
4. Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary
5. University of Veterinary Medicine, Dept. of Biomathematics and Informatics, Budapest, Hungary
6. Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
7. Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary