PhD Scientific Days 2022

Molecular Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Pilot Study of Radiofrequency Radiation Impacted Bystander Effect on Dermal Fibroblast Cells In Vitro

Előadó neve

Szilágyi, Zsófia, MSc

Előadó munkahelye

National Public Health Center, Department of Radiobiology and Radiohygiene, Non-ionizing Radiation Unit

Előadó telefonszáma

+36304610620

Előadó e-mail címe

szilagyi.zsofia@phd.semmelweis.hu

Az előadás címe

Pilot Study of Radiofrequency Radiation Impacted Bystander Effect on Dermal Fibroblast Cells In Vitro

Szerző(k) neve és munkahelye

Zsófia Szilágyi1,2, Bertalan Pintér1,2, Erika Szabó1, Györgyi Kubinyi1, György Thuróczy1*
1 National Public Health Center, Department of Radiobiology and Radiohygiene, Non-ionizing Radiation Unit, Budapest
2 Doctoral School of Theoretical and Translation Medicine, Semmelweis University, Budapest

Bemutatás módja

Poszter

Szekció

Molecular Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

English

Preferred session

Molecular Sciences

Összefoglaló szövege

The International Agency for Research on Cancer classifies radiofrequency (RF) radiation as “possible carcinogenic to humans” (Group 2B) since 2011. In the last decade the exposure to RF radiation emitted by wireless devices has increased in the human environment, whereupon has raised concerns about its health effects. With the development of new generations’ wireless technologies (3G, 4G, WiFi, 5G) the used frequency band increases, the penetration depth into human tissue decreases. This means that most of the RF power is absorbed in the skin of the body. Radiation-induced bystander effect (RIBE) is a well-known phenomenon, defined as a variety of stress induced response in non-irradiated cells resembling that observed in directly irradiated cells. Molecular signals secreted by irradiated cells can be carried far apart, possibly affecting distant targets.
We would like to investigate whether RF radiation has any effect on RIBE. Here we present a pilot study about RF radiation impacted bystander effect on the human skin.
In vitro experiments were performed on normal human dermal fibroblasts, when these cells were exposed to 0.5 Gy dose of ionizing radiation and 1950 MHz RF irradiation. Bystander effects observations were achieved by media transfer. Fibroblasts were exposed to ionizing radiation. One hour later cell culture media were collected and transferred to native fibroblasts, which were then exposed to 24 hours of RF radiation. Genetic aberration was measured by Cytokinesis-block Micronucleus Assay.
This is an ongoing study, the final results will be presented at the meeting.
This study SUPPORTED BY THE ÚNKP-21-3-I-SE-12, NEW NATIONAL EXCELLENCE PROGRAM OF THE MINISTRY FOR INNOVATION AND THECHNOLOGY FROM THE SOURCE OF THE NATIONAL RESEARCH, DEVELOPMENT AND INNOVATION FUND.

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Dr. György Thuróczy

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6830

Start

12:55

End

13:00

Authors (legacy)

Zsófia Szilágyi1,2, Bertalan Pintér1,2, Erika Szabó1, Györgyi Kubinyi1, György Thuróczy1*
1 National Public Health Center, Department of Radiobiology and Radiohygiene, Non-ionizing Radiation Unit, Budapest
2 Doctoral School of Theoretical and Translation Medicine, Semmelweis University, Budapest