PhD Scientific Days 2022
Budapest, 6-7 July 2022
Clinical Medicine I. (Poster discussion will take place in the Aula during the Coffee Break)
Echocardiographic assessment of the left atrium for categorization of left ventricular diastolic function in heart transplant recipients
Előadó neve
Dr. Assabiny, Alexandra
Előadó munkahelye
SEMMELWEIS UNIVERSITY HEART AND VASCULAR CENTRE
Előadó telefonszáma
703107819
Előadó e-mail címe
assabinyalexandra@gmail.com
Az előadás címe
Echocardiographic assessment of the left atrium for categorization of left ventricular diastolic function in heart transplant recipients
Szerző(k) neve és munkahelye
Alexandra Assabiny, Teszák Tímea, Borbála Edvi, Ákos Király, Zoltán Tarjányi, Nóra Parázs, Zsófia Szakál-Tóth, István Hartyánszky, Zoltán Szabolcs, Bálint Károly Lakatos, Attila Kovács, Béla Merkely, Balázs Sax
Heart and Vascular Centre of Semmelweis University
Bemutatás módja
Poszter
Szekció
Clinical Medicine I. (Poster discussion will take place in the Aula during the Coffee Break)
Language of the presentation
Hungarian
Preferred session
Clinical Medicine
Összefoglaló szövege
Introduction: Echocardiographic assessment of left ventricular (LV) diastolic function remains challenging after heart transplant (HTx). However, its evaluation is of particular importance as diastolic dysfunction (DD) may reveal allograft rejection or vasculopathy. Left atrial strain (LAS) appears as a promising tool in categorizing diastolic function.
Aim: We aimed to evaluate the structural and functional characteristics of left atrium (LA) in determining LV diastolic function in adult HTx recipients.
Methods: We analyzed serum NT-terminal pro-brain natriuretic peptide (NT-proBNP) levels and transthoracic echocardiograms of 27 patients 1 and 4 months following HTx. To derive E/e’ ratio, we characterized mitral inflow velocities (v) by pulsed-wave Doppler and mitral annular v using tissue Doppler imaging. Peak velocity of tricuspid regurgitation (TR vmax) was obtained by continuous-wave Doppler. We evaluated LA volume index (LAVi) using biplane area-length method and LA reservoir, conduit and contractile function by speckle tracking-derived LAS. Data values were given as mean±standard deviation. Statistical analysis was performed using t-test or Spearman correlation after assessment of normality.
Results: Average E/e’ (11.9±4.3 vs. 8.7±2.1; p=0,004), septal e’ v (6.6±1.9 cm/s vs. 7.7±1.8 cm/s; p=0.045), lateral e’ v (11.2±2.8 cm/s vs. 13.7±3.1 cm/s; p<0.001) and TR vmax (2.7±0.3 m/s vs. 2.5±0.3 m/s; p<0.001) improved significantly over time. LAVi and LAS did not change significantly. LAS was reduced compared to normal values from the literature. NT-proBNP levels decreased significantly (8543±8413 pg/ml vs. 1000±846 pg/ml; p<0.001). There were no strong correlations between LA reservoir strain and TR vmax, septal or lateral e’ v, average E/e’, LAVi or NT-proBNP level.
Conclusions: Significant improvement of the guideline-recommended diastolic parameters independent of LA and decreased incidence of DD suggest that restrictive pattern of the graft subsides over time. Hence, LA structural and functional impairment cannot be assessed exclusively as secondary consequence of DD and elevated LV filling pressure but might be primary characteristics related to surgical techniques. Relevance of LAVi and LAS in determining LV diastolic function is limited after HTx.
University and Doctoral School
Semmelweis University, Doctoral School of Theoretical and Translational Medicine
Supervisor
Dr. Kovács Attila
Publication of my abstract
I give consent to the publication of my abstract on the website of the congress.
Kind
Szabad
Status
elfogadva
Accepted presentation method
poszter
Előadás fájl jóváhagyás
nem rendelkezett róla
Előadó
6847
Start
11:00
End
11:05
Authors (legacy)
Alexandra Assabiny, Teszák Tímea, Borbála Edvi, Ákos Király, Zoltán Tarjányi, Nóra Parázs, Zsófia Szakál-Tóth, István Hartyánszky, Zoltán Szabolcs, Bálint Károly Lakatos, Attila Kovács, Béla Merkely, Balázs Sax
Heart and Vascular Centre of Semmelweis University