PhD Scientific Days 2022

Clinical Medicine II.

Gender differences in factors predicting ablation success and 1-year mortality in ventricular tachycardia patients with structural heart disease

Előadó neve

Dr. Tóth, Patrik

Előadó munkahelye

Heart and Vascular Center, Semmelweis University, Budapest

Előadó telefonszáma

+36306683268

Előadó e-mail címe

patrik.toth96@gmail.com

Az előadás címe

Gender differences in factors predicting ablation success and 1-year mortality in ventricular tachycardia patients with structural heart disease

Szerző(k) neve és munkahelye

Patrik Tóth M.D., Ferenc Komlósi M.D., Péter Vámosi M.D., Bence Arnóth, Ádám Kazay, Nándor Szegedi M.D., Ph.D., Zoltán Salló M.D., Katalin Piros M.D., Péter Perge M.D. Ph.D., István Osztheimer M.D. Ph.D., Béla Merkely M.D., Ph.D., D.Sc., László Gellér M.D., Ph.D., D.Sc., Klaudia Vivien Nagy M.D., Ph.D.
Heart and Vascular Center, Semmelweis University, Budapest

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine II.

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction
The incidence of ventricular tachycardias (VT) in women is known to be significantly lower compared to men and clinical studies assessing the predictors of VT ablation success tend to underrepresent the female population.
Aims
We aimed to identify gender specific predictors of 1-year VT recurrence and 1-year mortality after catheter ablation in patients with structural heart disease.
Method
Between January 2005 and December 2020, 284 patients underwent VT ablation with structural heart disease and sustained monomorphic VT. Medical history, laboratory results, imaging parameters, clinical properties of VTs, and procedural data were gathered in a structured database. The patients were followed up for one year after ablation, data on VT recurrence and all-cause mortality was collected.
Results
Out of the 284 patients, 33 (11,6%) were female. 13 (39,4%) of the women and 107 (43,1%) of the men experienced recurrence; one year mortality was 11 (35,5%) and 48 (19,8%) in women and men, respectively. Creatine-kinase was the only independent predictor of recurrence (p=0,03). In the male population implanted cardiac resynchronization therapy device (p=0,004) and elevated lactate-dehydrogenase (p<0,001) were significant with multivariate analysis. Regarding the 1-year mortality, use of angiotensin-convertase enzyme inhibitor/angiotensin receptor blocker and elevated sodium levels were associated with better outcomes with both uni- (p=0,008, p=0,02) and multivariate analysis (p=0,04, p=0,047). Older age (p=0,01) and electrical storm (p=0,049) were the independent predictors among men. Higher left ventricular ejection fraction (p=0,04) and longer mitral E-wave deceleration time (p=0,001) were associated with reduced mortality.
Conclusion
Predictors of VT ablation success and mortality show marked gender differences. Factors associated with ischemic events and consecutive heart failure are the main predictors among men, while untreated heart failure led to a worse outcome in the observed endpoints among women.
E-mail: patrik.toth96@gmail.com
Semmelweis University, Doctoral School of Theoretical and Translational Medicine
Supervisor: Klaudia Vivien Nagy, MD, PhD

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Dr. Nagy Klaudia Vivien

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6855

Start

15:00

End

15:15

Authors (legacy)

Patrik Tóth M.D., Ferenc Komlósi M.D., Péter Vámosi M.D., Bence Arnóth, Ádám Kazay, Nándor Szegedi M.D., Ph.D., Zoltán Salló M.D., Katalin Piros M.D., Péter Perge M.D. Ph.D., István Osztheimer M.D. Ph.D., Béla Merkely M.D., Ph.D., D.Sc., László Gellér M.D., Ph.D., D.Sc., Klaudia Vivien Nagy M.D., Ph.D.
Heart and Vascular Center, Semmelweis University, Budapest