PhD Scientific Days 2022

Clinical Medicine VII. (Poster discussion will take place in the Aula during the Coffee Break)

Retrospective Study and Multimodal Imaging of Primary Localized Cutaneous Amyloidosis

Előadó neve

Dr. Pálla, Sára

Előadó munkahelye

Semmelweis University, Department of Dermatology, Venereology and Dermatooncology

Előadó telefonszáma

+36303632658

Előadó e-mail címe

sarazakarias@gmail.com

Az előadás címe

Retrospective Study and Multimodal Imaging of Primary Localized Cutaneous Amyloidosis

Szerző(k) neve és munkahelye

Sára Pálla1, Eszter Tóth1, Dóra Plázár1, Klára Farkas1, Pálma Anker1, Enikő Kuroli1, Márta Medvecz1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine VII. (Poster discussion will take place in the Aula during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction. Primary localized cutaneous amyloidosis (PLCA) is a chronic dermatological disease, where amyloid deposits are present in the dermis. Its common subtypes are macular amyloidosis (MA), lichen amyloidosis (LA) and biphasic amyloidosis (BA). PLCA is rare in the caucasian population, limited data is available in the literature on its epidemiology and treatment, and the diagnosis is often delayed due to its aspecific clinical symptoms. High frequency ultrasound (HFUS) can be used as an objective tool in the examination and diagnosis of dermatologic diseases.
Aims. We performed a retrospective study analysing the clinical data of patients diagnosed with PLCA at Semmelweis University, Department of Dermatology, Venereology and Dermatooncology. We performed examinations with dermoscopy and HFUS on patients diagnosed with macular or lichen amyloidosis and examined the effect of topical therapy on the lesions.
Method. We reviewed the clinical data and photodocumentation of patients diagnosed with PLCA – and confirmed by histology – in the last 20 years at the Department of Dermatology, Venereology and Dermatooncology. Dermus SkinScanner, a 33 MHz HFUS device combined with optical imaging was used to examine the structure of the skin. The examinations were performed on the lesions initially, and 1 or 2 months after the patients started topical therapy. The HFUS recordings were analysed, the epidermal and dermal thickness was measured.
Results. From 2001 to 2022, 40 patients were diagnosed with PLCA, 22 patients presented with macular, 17 with lichen and 1 with biphasic amyloidosis. The mean age at the diagnosis was 54.0±15.1 years. The female to male ratio was 11:7 and 6:16 in LA and MA, respectively. LA appeared on the lower limbs in 11 patients (61%), while MA caused symptoms on the scapular region in 19 patients (86%). On HFUS recordings, we detected hypoechogenic areas in the dermis that can be the sign of the amyloid deposits.
Conclusion. We performed a retrospective study on the epidemiology of PLCA in our region. HFUS can be used as an objective tool in the diagnosis of PLCA and in examining the efficacy of different treatments.
Funding. This work was supported by grants from the National Research, Development and Innovation Office of Hungary– NKFIH (FK_131916, 2019), and EFOP-3.6.3-VEKOP-16-2017-00009.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Dr. Márta Medvecz PhD, Dr. Attila Patócs PhD Dsc

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6856

Start

12:00

End

12:15

Authors (legacy)

Sára Pálla1, Eszter Tóth1, Dóra Plázár1, Klára Farkas1, Pálma Anker1, Enikő Kuroli1, Márta Medvecz1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest