PhD Scientific Days 2022

Pathology and Oncology II. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Prognostic Relevance of Tumor Budding and Poorly Differentiated Clusters in Gastric Adenocarcinoma

Előadó neve

Dr. Kocsmár, Éva

Előadó munkahelye

Semmelweis University, Department of Pathology, Forensic and Insurance Medicine

Előadó telefonszáma

305819025

Előadó e-mail címe

kocsmar.eva@med.semmelweis-univ.hu

Az előadás címe

Prognostic Relevance of Tumor Budding and Poorly Differentiated Clusters in Gastric Adenocarcinoma

Szerző(k) neve és munkahelye

Éva Kocsmár1, Luca Szalai1,2, Jakab Ákos1, Ildikó Kocsmár1,3, Ildikó Szirtes1, Attila Szijártó4, Zsuzsa Schaff1, András Kiss1, Gábor Lotz1

1 Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary.
2 Department of Pathology, National Institute of Oncology, Budapest, Hungary.
3 Department of Urology, Semmelweis University, Budapest, Hungary.
4 Department of Surgery, Transplantation and Interventional Gastroenterology, Semmelweis University, Budapest, Hungary.

Bemutatás módja

Poszter

Szekció

Pathology and Oncology II. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Pathology and Oncology

Összefoglaló szövege

Introduction
Tumor budding (TB) is a histological phenomenon of various cancers, manifesting in invasion of the tumor stroma by individual malignant cells and/or small tumor cell clusters. TB is a well established prognostic factor in colorectal cancer. Recent studies indicated similar role of larger tumor cell clusters, namely poorly differentiated clusters (PDC). However, the prognostic value of TB is still controversal and PDC has not been investigated yet in gastric cancer.
Aims
Our aim was to identify the prognostic relevance of TB and PDC in a large cohort of gastric adenocarcinomas (GAC).
Methods
Haematoxylin and eosin stained slides of 290 GAC patients were investigated. Tumor bud was defined as an isolated tumor cell or a tumor cell cluster of up to four cells, while PDC as a tumor cell cluster of five or more cells. TBs and PDCs were evaluated according to the International Tumor Budding Consensus Conference and divided into low- (Grade 1+2) and high (Grade 3) groups.
Results
Univariable (Kaplan-Meier) analysis revealed significant negative correlation of both TB (p=0,0001) and PDCs (p=0,02) with overall survival (OS) in the total cohort and TB in the intestinal GACs. No significant correlation was found regarding the diffuse and mixed Lauren type GACs. Significant negative correlation with OS was also found by multivariable (Cox) analysis of PDCs in the total cohort, moreover in case of both TBing and PDCs in the intestinal type GACs. Logistic regression analysis with backward selection showed a significant positive correlation of TB with the presence of regional lymph node metastasis (p=0.009).
Conclusion
Both TB and PDCs are promising prognostic markers of gastric adenocarcinomas. Belonging to high budding group is associated with increased risk of nodal metastasis.
Funding
This study was partly supported by the New National Excellence Program (ÚNKP-21-4-I-SE-32; Ministry for Innovation and Technology).

University and Doctoral School

Semmelweis University, Doctoral School of Pathological Sciences

Supervisor

Dr. Gábor Lotz

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2223

Start

11:45

End

11:50

Authors (legacy)

Éva Kocsmár1, Luca Szalai1,2, Jakab Ákos1, Ildikó Kocsmár1,3, Ildikó Szirtes1, Attila Szijártó4, Zsuzsa Schaff1, András Kiss1, Gábor Lotz1

1 Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary.
2 Department of Pathology, National Institute of Oncology, Budapest, Hungary.
3 Department of Urology, Semmelweis University, Budapest, Hungary.
4 Department of Surgery, Transplantation and Interventional Gastroenterology, Semmelweis University, Budapest, Hungary.