PhD Scientific Days 2022

Pharmaceutical Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

The application opportunities of solid dispersions in 3D printed pharmaceutical dosage forms

Előadó neve

Dr. Balint, Basa

Előadó munkahelye

Semmelweis University - Department of Pharmaceutics

Előadó telefonszáma

+36309511779

Előadó e-mail címe

kysbasa@gmail.com

Az előadás címe

The application opportunities of solid dispersions in 3D printed pharmaceutical dosage forms

Szerző(k) neve és munkahelye

Balint Basa - Semmelweis University, Department of Pharmaceutics, Budapest
Nikolett Kállai-Szabó - Semmelweis University, Department of Pharmaceutics, Budapest
István Antal - Semmelweis University, Department of Pharmaceutics, Budapest

Bemutatás módja

Szóbeli

Szekció

Pharmaceutical Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

English

Preferred session

Pharmaceutical Sciences

Összefoglaló szövege

Introduction:

The interest towards additive manufacturing and its application in the pharmaceutical industry and personalized therapy seems to be continuously increasing. The transformation of the conventional technologies into an additive production line is more required than before.

Aims:

The study aims to explore and prepare excipient compounds which are appicable for FDM (Fused Deposition Modeling) 3D printers. Characterizing the most definitive excipients is also aim of this work, hence the critical parameters are well discovered, the critical excipients, their recommended portion and their predictable effect ont he quality of the intermediers and endproduct should be discovered.

Methods:

The prepared solid dispersions are processed with a hot-melt extruder (Felfil Evo, Torino, Italy) in order to produce thermoplastic filaments which can be utilized for 3D printed personalized drug delviery systems. The quality and surface characteristics of the prepared filaments were examined with Keyence VHX-7000 digital microscope (Keyence International, Mechelen, Belgium).
After the dissolution tests, executed with Hanson SR-8 Plus™ Dissolution Test Station (Hanson Research, Los Angeles, CA, USA) in biorelevant dissolution media (pH=1.2; 4.5; 6.8) the model substance was tracked and measured with Agilent 8453 UV-Visible Spectrophotometer (Agilent Technologies Ltd., Santa Clara, CA, USA).

Results:

Based on this work, different excipient compounds were prepared which can contain active ingredients. After the comparison of these matrixes, the 3D printer compatible samples were choosen and printability tests were also successful, and the dissolution tests approve the reproducibility of this novel and complex structures.

Conclusion:

All results considered, this innovative formulation can be an excellent auxiliary process for the produciton of drug containing filaments. Based on the fact, that this novel method gives the opportunity for the utilization of conventional tabletting excipients, the high process temperature used during FDM printing can be also decreased.

Funding:

SUPPORTED BY THE ÚNKP-21-21-3-II-SE-70 NEW NATIONAL EXCELLENCE PROGRAM OF THE MINISTRY FOR INNOVATION AND TECHNOLOGY FROM THE SOURCE OF THE NATIONAL RESEARCH, DEVELOPMENT AND INNOVATION FUND.

University and Doctoral School

Semmelweis University, Doctoral School of Pharmaceutical Sciences

Supervisor

István Antal

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4696

Start

12:15

End

12:30

Authors (legacy)

Balint Basa - Semmelweis University, Department of Pharmaceutics, Budapest
Nikolett Kállai-Szabó - Semmelweis University, Department of Pharmaceutics, Budapest
István Antal - Semmelweis University, Department of Pharmaceutics, Budapest