PhD Scientific Days 2022
Budapest, 6-7 July 2022
Pharmaceutical Sciences II. (Poster discussion will take place in the Aula during the Coffee Break)
Sleep-Wake Stage-Dependent qEEG Effects of Acute Tramadol Suggest a Potential Antidepressant Effect
Előadó neve
Koncz, Szabolcs
Előadó munkahelye
Department of Pharmacodynamics, Semmelweis University
Előadó telefonszáma
+36 70 225 4662
Előadó e-mail címe
koncz.szabolcs@pharma.semmelweis-univ.hu
Az előadás címe
Sleep-Wake Stage-Dependent qEEG Effects of Acute Tramadol Suggest a Potential Antidepressant Effect
Szerző(k) neve és munkahelye
Szabolcs Koncz1, Noémi Papp1, György Bagdy1,2,3
1 Department of Pharmacodynamics, Semmelweis University, Budapest
2 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest
3 NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
Bemutatás módja
Szóbeli
Szekció
Pharmaceutical Sciences II. (Poster discussion will take place in the Aula during the Coffee Break)
Language of the presentation
Hungarian
Preferred session
Pharmaceutical Sciences
Összefoglaló szövege
Introduction: Tramadol hydrochloride (TRA) is a widely prescribed opioid analgesic with additional inhibitory effects on the synaptic reuptake of serotonin (5-HT) and noradrenaline. Its potential use as an antidepressant in the treatment of major depression has been suggested. Most antidepressants show characteristic effects on quantitative electroencephalographic (qEEG) variables. For instance, we showed that chronic escitalopram treatment elicited an increase in gamma power during non-REM sleep. Similarly, acute administration of an 5-HT2C-R antagonist (SB-242084) with fast-onset antidepressant-like properties also elevated gamma power during non-REM sleep.
Aims: Our aim was to investigate the acute effects of tramadol on qEEG in different sleep-wake stages.
Methods: EEG-equipped male Wistar rats were treated with TRA (5, 15 and 45 mg/kg i.p.) or vehicle (VEH) at the beginning of the passive phase, and EEG, electromyogram (EMG) and motor activity (MOT) were recorded.
Results: QEEG analysis revealed that delta power during non-REM sleep was markedly increased by the two higher doses of TRA, 5 h after administration. However, the 15 mg/kg of TRA decreased delta power in the first hours. Delta power during wakefulness was also increased by TRA (15 and 45 mg/kg), 3 h after administration. Alpha power was decreased by TRA (15 and 45 mg/kg) during NREM sleep, while during wakefulness TRA showed no effect. All doses of TRA increased gamma power during NREM sleep. In contrast, TRA slightly reduced gamma power during wakefulness.
Conclusion: Our findings provide evidence that acute TRA affects qEEG in a sleep-wake stage-dependent manner. Some of these effects of TRA are similar to those observed in case of the chronic administration of 5-HT reuptake inhibitors or the acute effects of fast acting antidepressants. Therefore, qEEG effects of TRA suggest antidepressant-like properties, moreover, raise the possibility of faster acting antidepressant action.
Funding: This study was supported by the Development of Scientific Workshops of Medical, Health Sciences and Pharmaceutical Educations (EFOP-3.6.3-VEKOP-16-2017-00009).
University and Doctoral School
Semmelweis University, Doctoral School of Pharmaceutical Sciences
Supervisor
Prof. Dr. György Bagdy
Publication of my abstract
I give consent to the publication of my abstract on the website of the congress.
Kind
Szabad
Status
elfogadva
Accepted presentation method
szóbeli
Előadás fájl jóváhagyás
nem rendelkezett róla
Előadó
6142
Start
09:00
End
09:15
Authors (legacy)
Szabolcs Koncz1, Noémi Papp1, György Bagdy1,2,3
1 Department of Pharmacodynamics, Semmelweis University, Budapest
2 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest
3 NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest