PhD Scientific Days 2022

Clinical Medicine VI. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Does post-PCI FFR predict outcomes?

Előadó neve

Dr. Csanádi, Bettina

Előadó munkahelye

Gottsegen National Cardiovascular Center

Előadó telefonszáma

+36305342242

Előadó e-mail címe

csanadibettina@gmail.com

Az előadás címe

Does post-PCI FFR predict outcomes?

Szerző(k) neve és munkahelye

Bettina Csanádi MD, Gottsegen National Cardiovascular Center, Budapest
Zsolt Piróth MD, PhD, Gottsegen National Cardiovascular Center, Budapest

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine VI. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: Fractional flow reserve (FFR) is the reference method in decision making concerning revasularization. The role of FFR measured directly after drug eluting stent (DES) implantation (post-PCI FFR) is less clear in predicting major adverse cardiac events (MACE), furthermore it is not known which clinical parameters affect post-PCI FFR.
Aim: We sought to clarify the correlation between post-PCI FFR and clinical parameters, the relationship between post-PCI FFR and long-term MACE and determine the best post-PCI FFR cut-off in MACE prediction.
Method: We included patients with FFR-guided DES implantation and post-PCI FFR measurement in GOKVI between January 2009 and August 2019. We examined the relationship between post-PCI FFR and gender, age, LAD (vs. non-LAD) localization, indication (acute vs. chronic coronary syndrome), diabetes mellitus, and stent diameter, and the relationship between post-PCI FFR and target vessel-related MACE (cardiovascular mortality (CVD), non-fatal myocardial infarction (MI), recurrent revascularization (TVR)). Optimal diagnostic cut-off was determined by ROC curves.
Results: Post-PCI FFR measurement was performed in 423 coronary arteries of 362 patients. Post-PCI FFR was lower in LAD than in non-LAD localization (0.86 vs. 0.91, p<0.001). Female gender (0.89 vs. 0.87, p<0.001) and greater stent diameter resulted in higher post-PCI FFR (p<0.001), and there was no significant correlation between age, diabetes mellitus, PCI indication category and post-PCI FFR. During a median follow-up of 36 months, 23 CVD, 15 MI, and 31 TVR occurred. Follow-up was complete in 94.5% of patients. There was a significant inverse correlation between post-PCI FFR and MACE (p<0.001). The best post-PCI FFR cut-off for the total patient population, LAD and non-LAD lesions were 0.86 (p=0,0018), 0.83 (p=0,0012), and 0.91 (p=0,0458), respectively.
Conclusion: Post-PCI FFR in the LAD is significantly lower than in other coronaries. Female gender and greater stent diameter resulted in significantly higher post-PCI FFR. There is no significant difference between post-PCI FFR measured in acute vs. chronic coronary syndrome. FFR measured after DES implantation is a significant predictor of MACE-free long-term survival. The best post-PCI FFR cut-off to predict MACE was 0.86 for the whole patient population, 0.83 and 0.91 for LAD and non-LAD lesions.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Zsolt Piróth MD, PhD

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6917

Start

09:45

End

10:00

Authors (legacy)

Bettina Csanádi MD, Gottsegen National Cardiovascular Center, Budapest
Zsolt Piróth MD, PhD, Gottsegen National Cardiovascular Center, Budapest