PhD Scientific Days 2022

Clinical Medicine V. (Poster discussion will take place in the Aula during the Coffee Break)

Epidemiology, treatment strategy, natural disease course and surgical outcomes of patients with ulcerative colitis in Western Hungary – a population-based study between 2007 and 2018, data from the Veszprem County cohort

Előadó neve

Dr. Gonczi, Lorant, PhD

Előadó munkahelye

Department of Internal Medicine and Oncology, Semmelweis University

Előadó telefonszáma

+36308208250

Előadó e-mail címe

lorantgonczi@gmail.com

Az előadás címe

Epidemiology, treatment strategy, natural disease course and surgical outcomes of patients with ulcerative colitis in Western Hungary – a population-based study between 2007 and 2018, data from the Veszprem County cohort

Szerző(k) neve és munkahelye

Lorant Gonczi 1 , Laszlo Lakatos 2 , Zsuzsanna Kurti 1 , Petra Golovics 3 , Tunde Pandur 4 , Gyula David 2 , Zsuzsanna Erdelyi 2 , Istvan Szita 2 , Peter L. Lakatos 1,5
1. Department of Internal Medicine and Oncology, Semmelweis University, Budapest,
Hungary
2. Department of Gastroenterology, Ferenc Csolnoky Hospital, Veszprem, Hungary
3. Department of Gastroenterology, Hungarian Defence Forces Medical Centre, Budapest,
Hungary
4. Department of Gastroenterology, Grof Eszterhazy Hospital, Papa, Hungary
5. Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada

Bemutatás módja

Poszter

Szekció

Clinical Medicine V. (Poster discussion will take place in the Aula during the Coffee Break)

Language of the presentation

English

Preferred session

Clinical Medicine

Összefoglaló szövege

Background:
The number of prospective population-based studies evaluating the epidemiology of
ulcerative colitis (UC) are still limited from Eastern Europe.
Aim:
Our aim was to analyze the incidence and disease phenotype at diagnosis, treatment strategy, disease course and colectomy rates in a prospective population-based database including incident UC patients diagnosed between 2007 and 2018. The present study is a continuation of the Veszprem IBD cohort with a follow-up of the incidence and disease course of IBD since 1977.
Methods:
Data of 467 incident UC patients were analyzed (male/female: 236/231; median age at
diagnosis: 36 years(y) IQR: 25-54). Both in-hospital and outpatient records were collected
and comprehensively reviewed at diagnosis and during clinical follow-up. The mean length
of follow-up was 8.34y. Probability of medium-, long-term change in disease course and
surgical outcomes were analyzed using Kaplan–Meier survival analysis.
Results:
Adjusted mean incidence rate was 11.02 /10 5 person-years in this 12 year period. Prevalence
rate was 283.51/10 5 persons in 2011 and 317.79 in 2015. Disease extension was proctitis in
22.3%, left sided colitis in 43.9%, and extensive colitis in 33.8% of the patients at diagnosis.
The probability of disease progression into more extensive phenotype was 6.9% at 3 years,
8.3% at 5 years and 11.3% at 10 years. Distribution of maximal therapeutic steps during the
course of follow-up were 5-ASA in 46.9%, systemic corticosteroids in 16.3%, immunosuppressive therapy in 19.3%; anti-TNF biologic therapy in 12.2% and other biologic therapy in 4.3%. The probability of receiving biological therapy after diagnosis was 9.9% at 3 years, 13.9% at 5 years and 17.8% at 10 years in this cohort. The probability of colectomy was 1.5% at 1 year, 3.6% at 5 years and 4.4% at 10 years in Kaplan-Meier analysis.
Conclusions:
The incidence of UC in this period was high, similar to high-incidence areas in Western
Europe and to our previous data from the Veszprem cohort. Disease extension at diagnosis,
distribution of highest treatment step and the probability of disease proximal extension was
comparable to other European population-based data. Medium- and long-term colectomy
rates were lower compared to Western European centers, but somewhat higher than our
previous data from the Veszprem cohort (2002-2006).
Funding:
ÚNKP-21-4-II-SE-31

University and Doctoral School

Other, please specify in the next box

Other university and doctoral school, not listed above

Semmelweis University, post-doctoral UNKP

Supervisor

Gönczi Lóránt

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1103

Start

10:35

End

10:40

Authors (legacy)

Lorant Gonczi 1 , Laszlo Lakatos 2 , Zsuzsanna Kurti 1 , Petra Golovics 3 , Tunde Pandur 4 , Gyula David 2 , Zsuzsanna Erdelyi 2 , Istvan Szita 2 , Peter L. Lakatos 1,5
1. Department of Internal Medicine and Oncology, Semmelweis University, Budapest,
Hungary
2. Department of Gastroenterology, Ferenc Csolnoky Hospital, Veszprem, Hungary
3. Department of Gastroenterology, Hungarian Defence Forces Medical Centre, Budapest,
Hungary
4. Department of Gastroenterology, Grof Eszterhazy Hospital, Papa, Hungary
5. Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada