PhD Scientific Days 2022

Mental Health Sciences II. (Poster discussion will take place in the Aula during the Coffee Break)

Genetic association study of cognitive phenotypes of adult attention deficit hyperactivity disorder

Előadó neve

Dr. Somogyi, Szilvia

Előadó munkahelye

Department of Psychiatry and Psychotherapy

Előadó telefonszáma

+20/670-1462

Előadó e-mail címe

somogyi.szilvia@med.semmelweis-univ.hu

Az előadás címe

Genetic association study of cognitive phenotypes of adult attention deficit hyperactivity disorder

Szerző(k) neve és munkahelye

Somogyi Szilvia, SE Department of Psychiatry and Psychotherapy
Balogh Lívia, SE Department of Psychiatry and Psychotherapy
Kenézlői Eszter, SE Department of Psychiatry and Psychotherapy
Erzsébet Hantos-Horváth, SE Department of Psychiatry and Psychotherapy
Nemoda Zsófia, SE Department of Biochemistry
Réthelyi János, SE Department of Psychiatry and Psychotherapy

Bemutatás módja

Szóbeli

Szekció

Mental Health Sciences II. (Poster discussion will take place in the Aula during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Mental Sciences

Összefoglaló szövege

Introduction: Adult Attention Deficit Hyperactivity Disorder (aADHD) is a moderately heritable (70%) neurodevelopmental disorder that is the most commonly diagnosed childhood mental disorder. According to estimates a third of cases persist into adulthood, and although symptoms begin in childhood, recognitionin adulthood is becoming more common.
Thus genetic factors play significant role in the etology of the disease, the genetic background is still the subject of intensive research. Heterogenous clinical picture of disease (presence of subtypes, comorbidity and drug use) makes phenotypic characterisation more complicated. The study of such complex phenotypes is facilitated by the study of endophenotypes.
Aim: The aim of our study was to investigate the association between the cognitive phenotypes of adult ADHD and the genetic variants of the monoaminergic system.
Methods: Patients with ADHD (N=95) and age-, gender-, and education-matched controls (N=100) were included in the study. The aADHD patients were diagnosed and exained in the ADHD outpatient clinic of the SE Psychiatry and Psychotherapy Department, Semmelweis University. After a written consent, we used 8 tasks of the CANTAB neuropsychological software to characterize the cognitive phenotype, which allowed the study different cognitive areas such as reaction time, working memory, attention, impulsivity, and inhibition. For genetic testing, oral mucosa sample sample was collected which after isolation, was genotyped to functional variants of the following genes: catechol-O-methyltransferase (COMT), monoamine oxidase (MAO-A), dopamine receptor 4 (DRD4), dopamine transporter (DAT ), norepinephrine transporter (NET). GLM analyzes were performed for genetic association analysis.
Results: Our association analyzes confirm the genetic association of the genetic polymorphisms of the monoaminergic system and the symptom dimensions and cognitive abnormalities of ADHD. Our preliminary analyzes showed a significant relationship between the symptom dimension of impulsivity and the NET (rs3785143) gene (0.006).

University and Doctoral School

Semmelweis University, Doctoral School of Mental Health Sciences

Supervisor

Prof. Dr. Réthelyi János

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4743

Start

12:00

End

12:15

Authors (legacy)

Somogyi Szilvia, SE Department of Psychiatry and Psychotherapy
Balogh Lívia, SE Department of Psychiatry and Psychotherapy
Kenézlői Eszter, SE Department of Psychiatry and Psychotherapy
Erzsébet Hantos-Horváth, SE Department of Psychiatry and Psychotherapy
Nemoda Zsófia, SE Department of Biochemistry
Réthelyi János, SE Department of Psychiatry and Psychotherapy