PhD Scientific Days 2022

Clinical Medicine VI. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Infective endocarditis in adults with congenital heart disease - 11 years data from Hungary

Előadó neve

Dr. Bence, András

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36302454212

Előadó e-mail címe

contrastsides@gmail.com

Az előadás címe

Infective endocarditis in adults with congenital heart disease - 11 years data from Hungary

Szerző(k) neve és munkahelye

Dr. Bence András1, Gottsegen Gyorgy Hungarian Institute of Cardiology, Semmelweis University, Schooles of PhD Studies, Károly Rácz Doctoral School of Clinical Medicine, Budapest
Dr. Bálint Olga Hajlanlka PhD.2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest
Dr. Borbás Sarolta2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest
Dr. Dénes Mónika PhD.2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest
Prof. Dr. Andréka Péter PhD.2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest

Bemutatás módja

Poszter

Szekció

Clinical Medicine VI. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

English

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: Despite recent preventive strategies and advances in treatment the incidence and mortality rate of infective endocarditis (IE) remains high in Adult Congenital Heart Disease (ACHD) patients.
Aim: In our retrospective study we assessed the clinical and microbiological characteristics, inhospital and one year mortality rates of ACHD patients (pts.) admitted with IE in our tertiary referral hospital between 2010 and 2020.
Method: Definitive diagnosis of IE were in agreement with modified Duke’s criteria. Inhospital baseline data and up to one year follow-up data were collected from the hospital records. ACHD pts. were classified based on their lesion severity. Survival data and mortality predictors were analysed by Kaplan-Meier estimator and by uni and multivariate model.
Results: 60 cases had been treated with IE. Mean age was 37 ± 11.3 years (18-69), and most of them (76.6%, n=46) were men. ACHD complexity was as following: simple 66.7% (n=40), moderate 20% (n=12) and severe 13.3% (n=8). Most common pre-existing congenital cardiac abnormality was bicuspidal aortic valve seen in 52% (n=31) of cases. 62% (n=37) of pts. had previous heart surgery. Majority of pts. had a left sided IE (85%, n=51). IE related hospital stay was mean 28 ± 9 days. 30% of pts. (n=18) had an invasive procedure within 6 months preceding the IE diagnosis. Besides common bacterinemia caused by Staphylococcus (33%, n=20) and Streptococcus (25%, n=15), 18% (n=11) of pts. had negative blood culture. IE affected 36 pts. with a native valve, and all 16 with an artificial valve. 77% of patients required surgical intervention, immediate or urgent surgery in 22 and elective in 24 pts. Inhospital mortality was 13%, the majority 5 out of 8 pts. having an immediate/emergent surgical intervention. IE was complicated by acute heart failure in 17 (28%) and by stroke in 4 (6.7%) pts. During one year follow-up 21 pts. (38%) remained with chronic heart failure, and 3 more died. There was no significant difference in mortality between ACHD complexity groups, and no significant predictors of mortality were found.
Conclusion: The most common ACHD lesion affected by IE was bicuspid aortic valve. Two-third of pts. required surgical intervention, those with immediate/emergent surgery having a 22% early mortality rate. ACHD complexity was not related to early or late outcome in this population.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Prof. Dr. Andréka Péter PhD., Dr Dénes Mónika PhD.

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6932

Start

11:20

End

11:25

Authors (legacy)

Dr. Bence András1, Gottsegen Gyorgy Hungarian Institute of Cardiology, Semmelweis University, Schooles of PhD Studies, Károly Rácz Doctoral School of Clinical Medicine, Budapest
Dr. Bálint Olga Hajlanlka PhD.2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest
Dr. Borbás Sarolta2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest
Dr. Dénes Mónika PhD.2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest
Prof. Dr. Andréka Péter PhD.2, Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest