PhD Scientific Days 2022

Pharmaceutical Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Formulation of Modified PVA-based Electrospun Fibrous Scaffolds for Changes the Solubility Property of the Drug-carrier Matrix

Előadó neve

Dr. Kazsoki, Adrienn, PhD

Előadó munkahelye

University Pharmacy Department of Pharmacy Administration, Semmelweis University

Előadó telefonszáma

+36302060093

Előadó e-mail címe

kazsoki.adrienn@pharma.semmelweis-univ.hu

Az előadás címe

Formulation of Modified PVA-based Electrospun Fibrous Scaffolds for Changes the Solubility Property of the Drug-carrier Matrix

Szerző(k) neve és munkahelye

Adrienn Kazsoki1, Romána Zelkó1
1University Pharmacy Department of Pharmacy Administration, Budapest

Bemutatás módja

Poszter

Szekció

Pharmaceutical Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences

Összefoglaló szövege

Introduction
Ocular inserts, which are polymer-based innovative medical devices that can be formulated by fiber-forming techniques, offer a new therapeutic edge in the drug treatment of eye diseases. Among these processes, electrospinning is a commonly used, cost-effective continuous technology. Fibrous inserts can ensure the controlled release of embedded active ingredients and their stability on the ocular surface, making them good therapeutic alternatives to currently available products.
Aims
The purpose of the present project is to formulate polyvinyl alcohol/tetraetoxisilane (PVA-TEOS)-based soluble/partially soluble/insoluble inserts containing different model drugs, to investigate their usage as drug carrier matrix, to study their morphological and physicochemical properties, and to determine the in vitro drug release profile of the fibrous insert.
Methods
Electrospun samples were prepared from the different compositions of PVA-TEOS precursor solutions. The morphology of the samples was investigated by scanning electron microscopy, the solid-state characterization was carried out by Fourier-transform infrared (FT-IR) spectroscopy. The solubility and drug-release profile of the carriers were also monitored.
Results
The effect of the PVA concentration was investigated in three levels (10, 12, 14 %w/w), For each of the concentrations five PVA:TEOS mass ratios (5:0, 4:1, 3:2, 2:3, 1:4 m:m) were examined. The fiber formation ability of the precursor solution of different compositions and the morphology of the prepared electrospun sample were very diverse. In the case of the same polymer ratio, the increasing PVA concentration favored the fibrous structure, while with the increasing TEOS concentration the bead formation can be observed besides the fibrous structure. The degree of cross-linking between the polymers was well observed in the FTIR spectra, which was in good agreement with the drug-release kinetics of the embedded model drugs.
Conclusion
Starting from an aqueous solution, it may also be possible to formulate a completely insoluble fibrous matrix, which may be particularly important in the formulation of organic solvent-sensitive drugs, in cases where a water-insoluble drug carrier system is required.
Funding
This project is supported by the ÚNKP-21-4-II New National Excellence Program of the Ministry for Innovation and Technology.

University and Doctoral School

Semmelweis University, Doctoral School of Pharmaceutical Sciences

Supervisor

Romána Zelkó

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1195

Start

13:10

End

13:15

Authors (legacy)

Adrienn Kazsoki1, Romána Zelkó1
1University Pharmacy Department of Pharmacy Administration, Budapest