PhD Scientific Days 2022

Clinical Medicine I. (Poster discussion will take place in the Aula during the Coffee Break)

Renin-Angiotensin-Aldosterone System Inhibitors and Survival in Patients with Hypertension Treated with Immune Checkpoint Inhibitors

Előadó neve

Dr. Drobni, Zsófia Dóra, PhD

Előadó munkahelye

Heart and Vascular Center, Semmelweis University

Előadó telefonszáma

206701227

Előadó e-mail címe

zsofi.drobni@gmail.com

Az előadás címe

Renin-Angiotensin-Aldosterone System Inhibitors and Survival in Patients with Hypertension Treated with Immune Checkpoint Inhibitors

Szerző(k) neve és munkahelye

Zsofia D. Drobni, MD1,2, Olivier Michielin MD, PhD3,4, Thiago Quinaglia MD2, Daniel A. Zlotoff, MD PhD5, Leyre Zubiri, MD PhD6, Hannah K Gilman, BS2, Sama Supraja, BS2, Bela Merkely, MD1, Veronika Muller, MD7, Ryan J. Sullivan, MD6, Kerry L. Reynolds, MD6, Michael J. Pittet, PhD8, Rakesh K. Jain, PhD9, Tomas G. Neilan, MD, MPH2,5

1, Heart and Vascular Center, Semmelweis University, Budapest, Hungary
2, Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
3, Oncology Department, Precision Oncology Center, Lausanne, Switzerland
4, Oncology Department, Lausanne University Hospital, Lausanne, Switzerland
5, Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
6, Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
7, Department of Pulmonology, Semmelweis University, Budapest, Hungary
8, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
9, Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Bemutatás módja

Poszter

Szekció

Clinical Medicine I. (Poster discussion will take place in the Aula during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction and Aims: Preclinical studies indicate that the concurrent use of inhibitors of the renin–angiotensin–aldosterone system (RAAS) may improve outcomes in broad groups of cancer patients. There are limited data on the association between the use of RAAS inhibitors and outcomes among patients treated with immune checkpoint inhibitors (ICIs).
Methods: We performed a retrospective study of all patients treated with an ICI in a single academic network. Of 10,903 patients, 5,910 were on any anti-hypertensive medication. Of those on anti-hypertensive therapy, 3,426 were prescribed a RAAS inhibitor during ICI treatment and 2,484 were prescribed other anti-hypertensive medications. The primary outcome was overall survival in the entire cohort and in sub-groups by cancer types.
Results: Thoracic cancer (34%) and melanoma (16%) were the most common types of cancer. Those prescribed a RAAS inhibitor were older, more frequently male, and had more cardiovascular risk factors. In a Cox proportional hazard model, the concurrent use of RAAS inhibitors was associated with better overall survival (hazard ratio (HR):0.92, [95% Confidence Interval (CI):0.85-0.99], P=.032). Patients with gastrointestinal (HR:0.82, [95% CI: 0.67-1.01], P=.057) and genitourinary cancer (HR:0.81, [95% CI:0.64-1.01], P=.067) had a non-statistically significant better overall survival.
Conclusions: In this large retrospective study, patients with hypertension who were concomitantly taking a RAAS inhibitor during ICI therapy had better overall survival. This benefit was primarily noted among patients with gastrointestinal and genitourinary cancers. Prospective randomized trials are warranted to further evaluate and specify the benefit of RAAS inhibitors in cancer patients who receive ICI therapy.
Funding:

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Pál Maurovich Horvat

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2749

Start

11:20

End

11:25

Authors (legacy)

Zsofia D. Drobni, MD1,2, Olivier Michielin MD, PhD3,4, Thiago Quinaglia MD2, Daniel A. Zlotoff, MD PhD5, Leyre Zubiri, MD PhD6, Hannah K Gilman, BS2, Sama Supraja, BS2, Bela Merkely, MD1, Veronika Muller, MD7, Ryan J. Sullivan, MD6, Kerry L. Reynolds, MD6, Michael J. Pittet, PhD8, Rakesh K. Jain, PhD9, Tomas G. Neilan, MD, MPH2,5

1, Heart and Vascular Center, Semmelweis University, Budapest, Hungary
2, Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
3, Oncology Department, Precision Oncology Center, Lausanne, Switzerland
4, Oncology Department, Lausanne University Hospital, Lausanne, Switzerland
5, Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
6, Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
7, Department of Pulmonology, Semmelweis University, Budapest, Hungary
8, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
9, Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA