PhD Scientific Days 2022

Pharmaceutical Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Formulation and development of solid foam-based drug delivery systems

Előadó neve

Farkas, Dóra

Előadó munkahelye

Department of Pharmaceutics, Semmelweis University

Előadó telefonszáma

+36202087198

Előadó e-mail címe

doorifarkas@gmail.com

Az előadás címe

Formulation and development of solid foam-based drug delivery systems

Szerző(k) neve és munkahelye

Dóra Farkas, Antal István, Nikolett Kállai-Szabó
Semmelweis University, Department of Pharmaceutics, Budapest

Bemutatás módja

Poszter

Szekció

Pharmaceutical Sciences III. (Poster discussion will take place on the terrace of the room during the Coffee Break)

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences

Összefoglaló szövege

Foams are laminar difform colloidal systems, in which the discontinuous gas phase is dispersed in the continuous phase (that can be both liquid and solid) in the form of closed bubbles. In general, solid foams can be characterized with a porous structure, thus great specific surface area, low density, and weight. Despite these, significant mechanical strength can also be ensured, and these properties contribute to their diverse use in the medical and pharmaceutical fields, including the formulation of innovative drug delivery systems.

In the present research, we combined the advantages of solid foam systems with the use of 3D printing to increase patient compliance by formulating a more patient-centered dosage form. The aim of the study was to formulate solid foam-based drug delivery systems using different excipients and to investigate the effect of their quality and quantity on the final formulation, along with the influence of preparation circumstances. For this, custom-made nests were produced using a 3D printer and a vacuum forming machine. The foamy liquid-semi solid formulas undergoing different treatments (time of gas induction, quality, and quantity of excipients) were filled into these nests and the moisture content was reduced, resulting in a porous solid foam structure.

The results show substantial variety in the micro-, and macroscopic structure of the differently treated samples both before and after the solidification. Moreover, not only the appearance but also the behavior (e.g. rehydration) of the samples changed noticeably.

All in all, it can be concluded, that the proposed method is applicable for the production of solid foam-based drug delivery systems. Further, 3D printing combined with vacuum forming is an easy method for the production of patient-centric pharmaceutical dosage forms.

The research was supported by the ÚNKP-21-IV-1 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund.

University and Doctoral School

Semmelweis University, Doctoral School of Pharmaceutical Sciences

Supervisor

Nikolett Kállai-Szabó

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6105

Start

13:15

End

13:20

Authors (legacy)

Dóra Farkas, Antal István, Nikolett Kállai-Szabó
Semmelweis University, Department of Pharmaceutics, Budapest