PhD Scientific Days 2022

Clinical Medicine II.

Comparison of the efficacy of multispectral imaging and high-frequency ultrasound for the prediction of Breslow tumor thickness of melanoma

Előadó neve

Dr. Kiss, Norbert, PhD

Előadó munkahelye

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary

Előadó e-mail címe

norbert.f.kiss@gmail.com

Az előadás címe

Comparison of the efficacy of multispectral imaging and high-frequency ultrasound for the prediction of Breslow tumor thickness of melanoma

Szerző(k) neve és munkahelye

Norbert Kiss1, Maxime Buitendijk1, Noémi Nóra Varga1, Szabolcs Bozsányi1, Klára Farkas1, András Bánvölgyi1, Kende Lőrincz1, Ilze Lihacova2, Alexey Lihachev2, Antal Jobbágy1, Enikő Kuroli1,3, György Paragh4, Péter Holló1, Márta Medvecz1, and Norbert M. Wikonkál1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
2 Biophotonics Laboratory, Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia
3 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
4 Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine II.

Language of the presentation

English

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: The incidence of cutaneous melanoma shows a significant increase worldwide and is in the background of the majority of skin-cancer related mortality. The most important prognostic factor of melanoma is the Breslow tumor thickness that is provided by the histopathological evaluation of the excised tumor. The optimal surgical safety margin for melanoma excision is also based on the Breslow thickness that is only available before the surgery. Thus, often a reoperation is required if the primary surgical margin was not sufficient or in other cases, it reveals that a larger surgical margin was given than necessary. In this work, we aimed to compare two non-invasive imaging techniques, multispectral imaging (MSI) and high-frequency ultrasound (HFUS) for the preoperative prediction of the Breslow tumor thickness of melanoma.
Materials and methods: We carried out MSI using 405 nm (autofluorescence), 525 nm (green), 660 nm (red), and 940 nm (infrared) channels and 33 MHz high-frequency ultrasound imaging with optical guidance of primary cutaneous melanomas. Two subgroups with great clinical relevance were established to categorize the investigated melanomas based on the Breslow tumor thickness (<1 mm and >1 mm).
Results: We included 39 patients with primary cutaneous melanomas with a mean age of 65 ±12.40 years. The sex ratio was 46% female and 54% male. The mean histological Breslow tumor thickness was 1.928 ±1.589 mm. The intensity of the IR channel of the MSI had the strongest correlation with Breslow thickness (r:-0.678), thus, this was used to differentiate between the two subgroups. The sensitivity and specificity of the MSI were 78.9% and 85% and those of the HFUS were 89.5% and 100%, respectively. Both techniques showed a strong significant correlation with the Breslow tumor thickness (MSI: r: -0.698, p: <0.0001, 95% CI: -0.38306 to -0.4905, HFUS: r: 0.8881, p: <0.0001, 95% CI: 0,7955 to 0,9402).
Conclusions: In our study, in comparison with MSI, HFUS showed a stronger correlation with histological Breslow thickness. Further clinical studies are needed to investigate how these novel non-invasive techniques may aid the clinicians in the preoperative prediction of Breslow thickness in order to determine the appropriate surgical margins and required staging procedures for cutaneous melanoma.

Funding: This work was supported by ÚNKP-21-4-II-SE-10 (N.K.).

University and Doctoral School

Other, please specify in the next box

Other university and doctoral school, not listed above

Postdoctoral

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4113

Start

15:15

End

15:30

Authors (legacy)

Norbert Kiss1, Maxime Buitendijk1, Noémi Nóra Varga1, Szabolcs Bozsányi1, Klára Farkas1, András Bánvölgyi1, Kende Lőrincz1, Ilze Lihacova2, Alexey Lihachev2, Antal Jobbágy1, Enikő Kuroli1,3, György Paragh4, Péter Holló1, Márta Medvecz1, and Norbert M. Wikonkál1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
2 Biophotonics Laboratory, Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia
3 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
4 Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States