PhD Scientific Days 2023
Budapest, 22-23 June 2023
Translational Medicine II.
Modulated Electro Hyperthermia Enhances the Delivery and Antitumor Effects of Doxorubicin Encapsulated in Lyso-thermosensitive Liposome in 4T1 Mouse Model
Előadó neve
Aloss, Kenan
Neptun code
UL1GAP
Előadó munkahelye
Semmelweis University-Translational Medicine Institute
Előadó telefonszáma
06302411221
Előadó e-mail címe
kenan.aloss@phd.semmelweis.hu
Az előadás címe
Modulated Electro Hyperthermia Enhances the Delivery and Antitumor Effects of Doxorubicin Encapsulated in Lyso-thermosensitive Liposome in 4T1 Mouse Model
Szerző(k) neve és munkahelye
Kenan Aloss1, Csaba Schvarcz1, Pedro Leroy1, Nino Guinasvilli1, Mahak Bokhari Zahra1, Daniel Bocsi1, Zoltán Koós1, Peter Hamar1
1 Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary
Bemutatás módja
Szóbeli
Szekció
Translational Medicine II.
Language of the presentation
English
Preferred session
Theoretical and Translational Medicine
Összefoglaló szövege
Introduction: Modulated electro hyperthermia (mEHT) is an adjuvant cancer therapy which selectively targets the tumor. By the autofocusing of mEHT the selective and significant (+2.5°C) heating of even deeply situated tumors is possible. In this study, we investigated the possibility of using mEHT as a source of heat for thermosensitive liposomes (TSLs) to effectively enhance the delivery and in vivo efficacy of doxorubicin (DOX). Methods: a triple-negative breast cancer cell line (4T1), was orthotopically injected into Balb/C mice and treated with a combination of mEHT and lyso- thermosensitive liposomal doxorubicin (LTLD). Tumor growth inhibition was followed and DOX accumulation in the tumor was monitored by in vivo optical imaging. Results: LTLD+ mEHT combination was more effective in tumor growth inhibition compared to free DOX and pegylated liposomal DOX (PLD- Caelyx) as demonstrated by both tumor volume and tumor weight reduction. Moreover, the highest tumor destruction ratio (TDR) was observed in (LTLD+mEHT) group on HE stained samples. Furthermore, LTLD combined with mEHT resulted in the highest DOX accumulation in the tumor at 1 h and 24 h after treatment. On the other hand, LTLD exhibited similar toxicity to free DOX as demonstrated by body weight loss. In conclusion, mEHT can be an effective tool to improve tumor delivery and anti-tumor activity of DOX-encapsulated in TSL. Funding: SE250 ID: EFOP-3.6.3-VEKOP-16-2017-00009, ÚNKP-22-4-I-SE-15, 2021-1.2.4-TÉT-2021-00060, STIA-OTKA to PH
University and Doctoral School
Semmelweis University, Doctoral School of Theoretical and Translational Medicine
Supervisor
Peter Hamar
Publication of my abstract
I give consent to the publication of my abstract on the website of the congress.
Kind
Szabad
Status
elfogadva
Accepted presentation method
szóbeli
Előadás fájl jóváhagyás
nem rendelkezett róla
Előadó
6828
Start
13:15
End
13:30
Authors (legacy)
Kenan Aloss1, Csaba Schvarcz1, Pedro Leroy1, Nino Guinasvilli1, Mahak Bokhari Zahra1, Daniel Bocsi1, Zoltán Koós1, Peter Hamar1
1 Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary