PhD Scientific Days 2023

Clinical Medicine V.

Post-COVID interstitial lung disease in symptomatic patients after COVID-19 disease

Előadó neve

Fésü, Dorottya

Neptun code

JMLSUO

Előadó munkahelye

Department of Pulmonology

Előadó telefonszáma

+36303004563

Előadó e-mail címe

fesu.dorottya@gmail.com

Az előadás címe

Post-COVID interstitial lung disease in symptomatic patients after COVID-19 disease

Szerző(k) neve és munkahelye

Dorottya Fésü, Lőrinc Polivka, Enikő Bárczi, Edit Hidvégi, Gábor Horváth, Anikó Bohács, Veronika Müller

Semmelweis University, Faculty of Medicine, Department of Pulmonology, Budapest

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine V.

Language of the presentation

English

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: COVID-19 is often associated with long-lasting pulmonary symptoms. Data are scarce about interstitial lung disease (ILD) in patients following COVID-19 hospitalization with persistent symptoms.
Methods: We retrospectively reviewed all cases sent to pulmonary post-COVID evaluation due to persistent symptoms between February 2021 and February 2022 (N=318). All patients with suspected ILD (N=44) were reviewed at the multidisciplinary discussion. Patient characteristics, symptoms, time since hospitalization, detailed lung function measurements and 6-minute walk test (6MWT) were evaluated.
Results: The post-COVID ILD suspected group included more men (68.2 vs. 31.8%) with significantly older age compared to the control group (64.0±12.3 vs. 51.3± 14.9 years). Most patient needed hospital care for COVID-19 pneumonia (68.6% of all patients and 84.1% of ILD suspected group) and average time since hospitalization was 2.4±2.3 months. Persisting symptoms included fatigue (34%), dyspnoea (25.2%), cough (22.6%), and sleep disorders (insomnia 13.2%; sleepiness 8.2%). Post-COVID ILD presented more often with new symptoms of cough and sleepiness. Functional impairment, especially decreased walking distance and desaturation during 6-minute walk test (6MWT) were detected in the ILD-suspected group. Respiratory function test in the post-COVID ILD group showed slight restrictive ventilatory pattern (FVC: 76.7±18.1%, FEV1: 83.5±19.1%, TLC: 85.6±28.1%) and 6MWT did confirm post-exercise desaturation in 41% of patients. LDCT changes were mainly ground glass opacities (GGO) and/or reticular abnormalities in most cases affecting <10% of the lungs.
Conclusion: Our data indicate that suspected post-COVID ILD is affecting 13.8% of symptomatic patients. Slight functional impairment and mainly low extent GGO/reticulation were seen, while long-term lung structural changes need further evaluation.
Funding: This study was partly supported by 202-1.1.6-JÖVŐ-2021-00010 and Eötvös Loránd Research Network SA-45/2021. Dorottya Fesu was supported by the New National Excellence Program of The Ministry for Culture and Innovation from the source of the National Research, Development, and Innovation Fund ÚNKP-22-2-I. Lorinc Polivka is a participant of the MD-PhD excellence program and received scholarship from Semmelweis University EFOP-3.6.3-VEKOP-16-2017-00009).

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Veronika Müller MD, PhD, DSc

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7386

Start

15:15

End

15:30

Authors (legacy)

Dorottya Fésü, Lőrinc Polivka, Enikő Bárczi, Edit Hidvégi, Gábor Horváth, Anikó Bohács, Veronika Müller

Semmelweis University, Faculty of Medicine, Department of Pulmonology, Budapest