PhD Scientific Days 2023

Translational Medicine - Posters O

The Effect of Physical Prehabilitation on Induced Liver Regeneration After Partial Hepatectomy

Előadó neve

Dr. Lévay, Klára

Neptun code

DBAAW2

Előadó munkahelye

Department of Surgery, Transplantation and Gastroenterology, Semmelweis University

Előadó telefonszáma

+36204841077

Előadó e-mail címe

levay.klara96@gmail.com

Az előadás címe

The Effect of Physical Prehabilitation on Induced Liver Regeneration After Partial Hepatectomy

Szerző(k) neve és munkahelye

Noémi Daradics Dr. 1
András Fülöp Dr. 1
Attila Szijártó Prof. Dr. PhD 1

1 Department of Surgery, Transplantation and Gastroenterology, Semmelweis University

Bemutatás módja

Poszter

Szekció

Translational Medicine - Posters O

Language of the presentation

Hungarian

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: In the case of liver tumors the only curative treatment is liver resection, which can be a major surgical stress for patients, whose physical and nutritional status is inadequate. Additionally, in the postoperative period, catabolism is increased which could increase the morbidity and mortality rates. Prehabilitation could be easily applied to younger patients, while pharmacological therapy could be useful for elderly patients as it could improve their physical and nutritional status. Therefore, we studied the effect of physical prehabilitation on induced liver regeneration with special emphasis on the AMP-activated protein kinase (AMPK).
Aims: Studying the role of AMPK during liver regeneration induced by hepatectomy.
Method: 72 male Wistar rats were divided into control (C), physically prehabilitated (PP), and inhibited (I) groups. The C group was kept in the animal house for 5 weeks, while the PP and I groups had to run 5 times a week for a 5-week-long period. Additionally, the I group was injected with intraperitoneal injection of an AMPK inhibitor. After 5 weeks, animals were operated, and sacrificed after 0,24,72, and 168 postoperative hours. Metabolic status (bodyweight (bw) and composition (bc), intraperitoneal glucose tolerance test (IPGTT)), liver function (laboratory parameters, bile production, ICG (indocyanine green) clearance), and volumetric changes (regeneration rate (RR)) were investigated.
Results: The metabolic status, functional, and volumetric liver regeneration were favorable in the PP group compared to the C group. The I group was significantly deficient compared to the PP and the C groups following hepatectomy. The IPGTT was elevated while bw was increased in the I group compared to C and PP groups. Laboratory parameters were significantly increased, but bc, bile production, ICG clearance, and RR were significantly decreased in the I groups compared to the C and PP groups.
Conclusion: We showed that the AMPK could have a principal role in liver regeneration after hepatectomy and could be a potential target molecule for pharmacologic prehabilitation.
Funding: This study was supported by the Semmelweis University 250+ PhD Excellence Grant (121432/DIDIT/2022) and New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund(ÚNKP-22-3-I-SE-2)

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Attila Szijártó Prof. Dr.

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6849

Start

11:06

End

11:11

Authors (legacy)

Noémi Daradics Dr. 1
András Fülöp Dr. 1
Attila Szijártó Prof. Dr. PhD 1

1 Department of Surgery, Transplantation and Gastroenterology, Semmelweis University