PhD Scientific Days 2023

Neurosciences I.

Novel Pontine Inhibitory Nucleus Regulates Reward Experience

Előadó neve

Dr. Zichó, Krisztián

Neptun code

AY9H43

Előadó munkahelye

Institute of Experimental Medicine

Előadó telefonszáma

+36303648093

Előadó e-mail címe

zicho.krisztian@koki.hu

Az előadás címe

Novel Pontine Inhibitory Nucleus Regulates Reward Experience

Szerző(k) neve és munkahelye

Krisztián Zichó1,2, Réka Z. Sebestény1, Boldizsár Balog1,3, János Brunner1,4, Virág Takács1, Áron Orosz1,2, János Szabadics1,4, Gábor Nyiri1
1 Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest
2 János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest
3 Tamás Roska Doctoral School of Sciences and Technology, Pázmány Péter University, Budapest
4 Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Budapest

Bemutatás módja

Szóbeli

Szekció

Neurosciences I.

Language of the presentation

English

Preferred session

Neurosciences

Összefoglaló szövege

The lateral habenula (LHb) regulates behavioral flexibility that is essential for effective decision-making. LHb activity can facilitate aversion or reward-seeking behavior as a function of its excitatory/inhibitory inputs. However, despite LHb abundant connections with hindbrain areas the role of brainstem inputs are still unclear. Using viral tract tracing, immunohistochemistry, fluorescent- and electron microscopic imaging, in vitro electrophysiological recordings and optogenetic behavioral experiments in transgenic mice, we investigated a previously unrecognized gamma-aminobutyric acid (GABA)-ergic cell population in the pons. These cells localized beneath the 4th ventricle and establish inhibitory synapses in LHb. Their stimulation induced both acute and conditioned place preference in behavioral experiments, indicating its potential role in reward behavior. Conversely, inhibition of these pontine neurons caused acute and conditioned place avoidance, and their inhibition during aversive experience increased conditioned fear behavior even further, suggesting their fundamental role in fear regulation. Our results suggest that a novel GABAergic pontine nucleus has a major role in processing positive valence and reward-seeking behavior.

Funding: This project was supported by the ÚNKP-22-3-II-SE-7 New National Excellence Program of the Ministry of Innovation and by the EFOP-3.6.3-VEKOP-16-2017-00009 Semmelweis 250+ Excellence PhD Fellowship.

University and Doctoral School

Semmelweis University, János Szentágothai Doctoral School of Neurosciences

Supervisor

Gábor Nyiri

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5982

Start

09:45

End

10:00

Authors (legacy)

Krisztián Zichó1,2, Réka Z. Sebestény1, Boldizsár Balog1,3, János Brunner1,4, Virág Takács1, Áron Orosz1,2, János Szabadics1,4, Gábor Nyiri1
1 Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest
2 János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest
3 Tamás Roska Doctoral School of Sciences and Technology, Pázmány Péter University, Budapest
4 Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Budapest