PhD Scientific Days 2023

Neurosciences - Posters H

Altered Prefrontal Cortical Serotonergic Neurotransmission Is Associated With Post-weaning Social Isolation-induced Abnormal Social Behaviour

Előadó neve

Szebik, Huba

Neptun code

jsmlph

Előadó munkahelye

Institute of Experimental Medicine

Előadó telefonszáma

+36205738160

Előadó e-mail címe

sz.huba@yahoo.com

Az előadás címe

Altered Prefrontal Cortical Serotonergic Neurotransmission Is Associated With Post-weaning Social Isolation-induced Abnormal Social Behaviour

Szerző(k) neve és munkahelye

Huba Szebik 1,2, László Biró 1, Christina Miskolczi 1,2, Bíborka Bruzsik 1,2, Soma Szabó 1, Éva Mikics 1
1 Institute of Experimental Medicine, Translational Behavioural Neuroscience, Budapest, Hungary
2 Janos Szentagothai Doctoral School of Neurosciences, Semmelweis University, Budapest

Bemutatás módja

Poszter

Szekció

Neurosciences - Posters H

Language of the presentation

English

Preferred session

Neurosciences

Összefoglaló szövege

Introduction: Early-life social adversity is a significant risk factor for developing antisocial behaviors during adulthood. In this study, we aimed to investigate the neuronal basis of behavioral abnormalities induced by early-life adversity using the post-weaning social isolation model in mice.

Aims: Our study aimed to assess the impact of early-life social isolation on aggressive behavior in adult mice and to investigate the neuronal activity and serotonergic signaling in the prefrontal cortex, a brain region that controls social behavior.

Method: We used the resident-intruder test to evaluate aggressive behavior in adult mice isolated or housed socially from weaning until adulthood. We assessed the neuronal activity of the prefrontal cortex using c-Fos immunohistochemistry and investigated changes in the serotonergic system through immunohistochemical staining against 5-HT and SERT.

Results: Isolated mice showed abnormal aggressive behavior compared to group-housed animals. Fighting increased neuronal activation in the medial prefrontal cortex, and social isolation caused hyperactivation of the medial prefrontal cortex. Both SERT and 5-HT density increased in the medial prefrontal cortex of animals participating in the resident-intruder test. SERT density showed a positive correlation with behavioral parameters of aggressive behavior in isolated animals, which was absent in group-housed littermates.

Conclusion: Our findings suggest that early-life social isolation leads to abnormally aggressive behavior during adulthood, which is associated with neuronal hyperactivation of the prefrontal cortex and disturbed serotonergic signaling. These results highlight the importance of early-life social experiences in shaping adult behavior and the potential of targeting the serotonergic system to treat antisocial behaviors.

Funding: Hungarian Brain Research Program: Eva Mikics #2017-1.2.1-NKP-2017-00002; NKFI National Research, Development and Innovation Office: Eva Mikics #K125390; Eotvos Lorand Research Network: Eva Mikics #SA-49/2021; National Laboratory of Translational Neuroscience: Eva Mikics #RRF-2.3.1-21-2022-00011

University and Doctoral School

Semmelweis University, János Szentágothai Doctoral School of Neurosciences

Supervisor

Éva Mikics

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7429

Start

11:00

End

11:05

Authors (legacy)

Huba Szebik 1,2, László Biró 1, Christina Miskolczi 1,2, Bíborka Bruzsik 1,2, Soma Szabó 1, Éva Mikics 1
1 Institute of Experimental Medicine, Translational Behavioural Neuroscience, Budapest, Hungary
2 Janos Szentagothai Doctoral School of Neurosciences, Semmelweis University, Budapest