PhD Scientific Days 2023

Clinical Medicine - Posters I

FDG-PET Brain Imaging in the Evaluation and Follow-up of COVID-19

Előadó neve

Dr. Száraz, Lili

Neptun code

V13JIL

Előadó munkahelye

Semmelweis University, Medical Imaging Centre, Department of Nuclear Medicine

Előadó telefonszáma

+36704153891

Előadó e-mail címe

lili.szaraz@hotmail.com

Az előadás címe

FDG-PET Brain Imaging in the Evaluation and Follow-up of COVID-19

Szerző(k) neve és munkahelye

Lili Száraz1, Sándor Czibor1, Judit Simon2, Márk Di Giovanni2, Veronika Müller3, Pál. Maurovich-Horvat2, Gábor Csukly4, Tamás Györke1
1Department of Nuclear Medicine, Medical Imaging Centre, Semmelweis University, Budapest
2Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest
3Department of Pulmonology, Medical Imaging Centre, Semmelweis University, Budapest
4Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest

Bemutatás módja

Poszter

Szekció

Clinical Medicine - Posters I

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: The novel coronavirus disease (COVID-19) is caused by the respiratory infection of SARS-CoV-2 virus and is characterized by a multisystemic inflammation, presenting with a wide spectrum of symptoms. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) is a promising imaging method in the evaluation of acute-phase and late changes in the central nervous system.
Aims: Our primary aim was to identify brain metabolic changes in COVID-19 patients versus controls at baseline and 3 months follow-up.
Methods: A single-centre, prospective clinical study was initiated where FDG-PET/CT was performed in adult COVID-19 patients during acute, infective state and 3 months later. Brain FDG-PET images were evaluated with a software utilizing a built-in, age-matched normal database and the degree of the differences (Z-scores) were investigated at the two imaging timepoints.
Results: We present the data of 36 patients (14 women, 22 men), with a mean age of 52 years (42-75 years). In the acute, infective state, the majority of the patients presented with diffuse, significant cortical hypometabolism whereas at 3 months follow- up, the involved regions showed a marked and often complete metabolic normalization. The most common regions with residual hypometabolism at 3 months were the medial prefrontal and medial temporal regions and the anterior cingulate. Also, these regions showed the proportionally lowest rates of normalization. Hypometabolism was the least frequent in the cerebellum at the acute, infective state and its FDG-uptake showed a nomalization in all but one case.
Conclusion: Residual hypometabolism is common in the areas encompassing the orbitofrontal cortex and the limbic system while the cerebellar cortex was relatively spared. However, our study is limited by the corticosteroid-effect in the scans performed at the acute, infective state and furthermore, the fact that no metabolic data is available of the patients before SARS-CoV-2 infection.
Funding: SE 250+ Excellence PhD Scholarship, SUPPORTED BY THE ÚNKP-22-3-I-SE-38 NEW NATIONAL EXCELLENCE PROGRAM OF THE MINISTRY FOR CULTURE AND INNOVATION FROM THE SOURCE OF THE NATIONAL RESEARCH, DEVELOPMENT AND INNOVATION FUND.”

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Dr. Györke Tamás

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7438

Start

11:42

End

11:47

Authors (legacy)

Lili Száraz1, Sándor Czibor1, Judit Simon2, Márk Di Giovanni2, Veronika Müller3, Pál. Maurovich-Horvat2, Gábor Csukly4, Tamás Györke1
1Department of Nuclear Medicine, Medical Imaging Centre, Semmelweis University, Budapest
2Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest
3Department of Pulmonology, Medical Imaging Centre, Semmelweis University, Budapest
4Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest