PhD Scientific Days 2023

Mental Health Sciences I.

Inverse relationship between trait-anxiety and periaqueductal gray connectivity in migraineurs compared to tension-type headache patients

Előadó neve

Dr. Gecse, Kinga

Neptun code

X9LFNV

Előadó munkahelye

Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University

Előadó telefonszáma

+36202969397

Előadó e-mail címe

gecse.kinga@semmelweis-univ.hu

Az előadás címe

Inverse relationship between trait-anxiety and periaqueductal gray connectivity in migraineurs compared to tension-type headache patients

Szerző(k) neve és munkahelye

Kinga Gecse 1,2, Norbert Károlyi1 ,2, Angéla Hammer 2,3, Dóra Dobos 1,2, , Csaba Aranyi 4, Miklós Emri 4, György Bagdy 1,2, Gabriella Juhász 1,2
1 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest
2 NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
3 Institute of Psychology, ELTE Eötvös Loránd University, Budapest
4 Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen

Bemutatás módja

Szóbeli

Szekció

Mental Health Sciences I.

Language of the presentation

Hungarian

Preferred session

Mental Sciences

Összefoglaló szövege

Introduction: Tension-type headache and migraine are the most common neurological disorders in the world. Both types of headache are often comorbid with anxiety disorders. The comorbidity may affect specific regions such as the periaqueductal gray matter (PAG) which is important in negative emotion regulation and pain modulatory system. However, less is known about the neuronal differences between the relationship of anxiety with migraine and tension-type headaches.
Aims: Our aim was to investigate the effect of trait-anxiety on periaqueductal gray matter functional connectivity in migraine patients compared to tension-type headache patients.
Methods: Functional connectivity (FC) analysis with PAG as seed region was conducted involving 37 episodic migraine without aura and 30 tension-type headache patients. They were headache and medication free. Trait-anxiety was measured with trait version of State-Trait Anxiety Inventory (STAI-T). To investigate the differences between the relationship of trait-anxiety and PAGFC in migraineurs compared to tension-type headache group, STAI-T scores were used as covariates in interaction with PAG-FC in two sample t-tests using the Statistical Parametric Mapping (SPM12) toolbox in MATLAB environment.
Results: Significant difference was found between migraine and tension-type headache group in the relationship of trait-anxiety and PAG-FC with superior frontal gyrus (left SFG: pFWE=0.001, right SFG: pFWE=0.016). Namely, increased trait-anxiety level was correlated with higher PAG-SFG connectivity in tension-type headache patients. However, increased trait-anxiety was correlated with decreased PAG-SFG connectivity in migraine patients.
Conclusion: Our results suggest that anxiety may contribute differently to migraine and tension headache patomechanism. Previous studies showed that SFG activity is reduced in pain stimuli, but increases with higher trait-anxiety. In line with this, anxiety may be associated with decreased pain inhibition pathways in migraine patients. Meanwhile in tension-type patients, anxiety may be contributed to cortical hypersensitivity.
Funding: Development of scientific workshops of medical, health sciences and pharmaceutical educations (EFOP-3.6.3-VEKOP-16-2017-00009); ÚNKP-22-3-II-SE-27; 2017-1.2.1-NKP-2017-00002, NAP2022-I-4/2022; TKP2021-EGA-25; OTKA (K143391); ERA PerMed (2019-2.1.7-ERA-NET-2020-00005).

University and Doctoral School

Semmelweis University, Doctoral School of Mental Health Sciences

Supervisor

Gabriella Juhász Dr. and György Bagdy Dr.

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5972

Start

16:00

End

16:15

Authors (legacy)

Kinga Gecse 1,2, Norbert Károlyi1 ,2, Angéla Hammer 2,3, Dóra Dobos 1,2, , Csaba Aranyi 4, Miklós Emri 4, György Bagdy 1,2, Gabriella Juhász 1,2
1 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest
2 NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
3 Institute of Psychology, ELTE Eötvös Loránd University, Budapest
4 Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen