PhD Scientific Days 2023

Clinical Medicine II.

Comparing EQ-5D-5L, PROPr, SF-6D and TTO utilities in patients with chronic skin diseases

Előadó neve

Ákos, Szabó, MSc

Neptun code

T6KNUB

Előadó munkahelye

Department of Health Policy, Corvinus University of Budapest & Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University

Előadó telefonszáma

+36301804801

Előadó e-mail címe

akos.szabo@uni-corvinus.hu

Az előadás címe

Comparing EQ-5D-5L, PROPr, SF-6D and TTO utilities in patients with chronic skin diseases

Szerző(k) neve és munkahelye

Ákos Szabó1,2, Dr. Valentin Brodszky1, and Dr. Fanni Rencz1

1 – Department of Health Policy, Corvinus University of Budapest, 8 Fővám tér, H-1093, Budapest, Hungary
2 – Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, 26 Üllői út, H-1085 Budapest, Hungary

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine II.

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: We aim to compare the measurement properties of three indirect (EQ-5D-5L, Patient-Reported Outcomes Measurement Information System-Preference [PROPr] based on PROMIS-29+2 and Short-form 6-dimensions [SF-6Dv1] based on SF-36) and one direct (conventional 10-year time trade-off [TTO]) utility assessment methods in patients with chronic skin diseases.
Method: In November 2020, 120 patients with physician-diagnosed chronic skin diseases (mean age 49 years, female 61%) completed an online cross-sectional survey in Hungary. US value sets were used for the EQ-5D-5L and PROPr, and the UK one for the SF-6D. Floor, ceiling, convergent and known-group validity were compared across the four utility measures. Known-groups were created based on the first item of SF-36 and the first four items of PROMIS Global Health (general health, quality of life, physical and mental health). The agreement between utilities was analysed using Bland-Altman plots.
Results: Mean ± SD utilities of the EQ-5D-5L, PROPr and SF-6D were 0.79±0.24, 0.47±0.24 and 0.71±0.15, while 0.89±0.23 for the TTO. The ceiling was 65% for the TTO, 27% for the EQ-5D-5L, 2% for the SF-6D and 0% for the PROPr. Indirectly assessed utilities showed strong correlations with each other (range of rs=0.771 to 0.987), while the TTO exhibited weak correlations with indirect utilities (range of rs=0.171 to 0.193). The EQ-5D-5L was able to better discriminate between known groups of patients defined based on general health, quality of life and physical health, while the SF-6D and PROPr outperformed the EQ-5D-5L for mental health problems. The Bland-Altman plots confirmed the good agreement between indirect utilities.
Conclusion: Utilities measured by different instruments showed a great variability in patients with chronic skin conditions. All indirect methods exhibited generally good measurement properties. Our findings help to understand the differences across these measures and support the choice of instrument for quality-adjusted life year calculations in cost-utility analyses.
Funding: Ákos Szabó’s work was supported by the ÚNKP-22-3-II-SE-5 - New National Excellence Programme (Új Nemzeti Kiválóság Program) of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation fund. Fanni Rencz’s work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00304/21) and the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (ÚNKP-22-5-CORVINUS-4).

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Other university and doctoral school, not listed above

-

Supervisor

Dr. Fanni Rencz

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6013

Start

16:15

End

16:30

Authors (legacy)

Ákos Szabó1,2, Dr. Valentin Brodszky1, and Dr. Fanni Rencz1

1 – Department of Health Policy, Corvinus University of Budapest, 8 Fővám tér, H-1093, Budapest, Hungary
2 – Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, 26 Üllői út, H-1085 Budapest, Hungary