PhD Scientific Days 2023

Clinical Medicine - Posters J

Retrospective study of primary localized cutaneous amyloidosis

Előadó neve

Dr. Pálla, Sára

Neptun code

P441QK

Előadó munkahelye

Semmelweis University, Department of Dermatology, Venereology and Dermatooncology

Előadó telefonszáma

0630/3632658

Előadó e-mail címe

sarazakarias@gmail.com

Az előadás címe

Retrospective study of primary localized cutaneous amyloidosis

Szerző(k) neve és munkahelye

Sára Pálla1, Eszter Tóth1, Enikő Kuroli1, Márta Medvecz1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest

Bemutatás módja

Poszter

Szekció

Clinical Medicine - Posters J

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction
Primary localized cutaneous amyloidosis (PLCA) is a chronic dermatologic condition where the deposition of amyloid proteins is located in the papillary dermis. Three subtypes of PLCA are differentiated, macular amyloidosis (MA), lichen amyloidosis (LA) and nodular amyloidosis (NA). Due its rarity in the Caucasian population, data on its epidemiology and therapeutic possibilities are limited.
Aims
The aim of the study was to share clinical data and our clinical experience in the therapeutic possibilities regarding this rare cutaneous disorder.
Method
In this retrospective study, we collected data of all PLCA cases diagnosed at the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University between January 1, 2004, and December 31, 2022. Distribution of symptoms, age, sex, comorbidities, skin phototype, disease duration, treatment modalities and response to therapy were assessed.
Results
41 patients diagnosed with PLCA were included in the study. Mean age at diagnosis was 54.6±15.2 years. MA was diagnosed in 22 patients and LA in 18 patients. Mean age at disease onset was 53±16.1 years. Most frequently, topical medium- or high-potency corticosteroid was applied, however, their effect on the symptoms was variable. In other cases, topical capsaicin, calcineurin inhibitor, phototherapy or oral retinoid was prescribed.
Conclusion
In this study, we provided epidemiologic characteristics of PLCA in the Caucasian population. We examined the effects of different therapeutic options on a large patient population, however further randomized controlled trials would be necessary to improve therapeutic possibilities for PLCA patients.
Funding
This work was supported by grants from the Hungarian National Research, Development and Innovation Office – NKFIH grant [FK_131916, 2019], and EFOP- 3.6.3-VEKOP-16-2017-00009.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Márta Medvecz

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6856

Start

11:30

End

11:35

Authors (legacy)

Sára Pálla1, Eszter Tóth1, Enikő Kuroli1, Márta Medvecz1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest