PhD Scientific Days 2023

Pharmaceutical Sciences II.

Efficacy of Peppermint Essential Oil for Reducing the Symptoms of Nausea and Vomiting: Systematic Review and Meta-Analysis

Előadó neve

Dorottya, Gergő, MSc

Neptun code

IRKLQD

Előadó munkahelye

Semmelweis University, Centre for Translational Medicine, Department of Pharmacognosy

Előadó telefonszáma

+36203943258

Előadó e-mail címe

gergo.dorottya@gmail.com

Az előadás címe

Efficacy of Peppermint Essential Oil for Reducing the Symptoms of Nausea and Vomiting: Systematic Review and Meta-Analysis

Szerző(k) neve és munkahelye

Dorottya Gergő1,2, Gantsetseg Garmaa2,3, Andrea Tóth-Mészáros2, Uyen Nguyen Do To2,4, Andrea Harnos5, Péter Hegyi,2,6,7 Rita Nagy2,6,8, András Bánvölgyi9, Attila Ványolós1,2, Dezső Csupor2,6,10
1 Department of Pharmacognosy, Semmelweis University, Budapest
2 Centre for Translational Medicine, Semmelweis University, Budapest
3 Institute of Translational Medicine, Semmelweis University, Budapest
4 András Pető Faculty, Semmelweis University, Budapest
5 Department of Biomathematics and Informatics, University of Veterinary Medicine Budapest, Budapest
6 Institute for Translational Medicine, Medical School, University of Pécs, Pécs
7 Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest
8 Heim Pál National Pediatric Institute, Budapest
9 Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine,
Semmelweis University, Budapest,
10 Institute of Clinical Pharmacy, University of Szeged, Szeged

Bemutatás módja

Szóbeli

Szekció

Pharmaceutical Sciences II.

Language of the presentation

English

Preferred session

Pharmaceutical Sciences

Összefoglaló szövege

Introduction
Nausea and vomiting are common symptoms that can occur in various situations, including postoperatively, as a result of chemotherapy, or during pregnancy. Pharmaceutical treatments for these symptoms are not always effective or have adverse effects. Peppermint oil could be a potential alternative option. There is no evidence-based knowledge about the efficacy of peppermint oil in treating nausea and vomiting symptoms and it needs further investigation.
Aims
To systematically evaluate the efficacy of peppermint oil in reducing the symptoms of nausea and vomiting during pregnancy (NVP), in postoperative nausea and vomiting (PONV) or in chemotherapy induced nausea and vomiting (CINV) compared to placebo in randomized controlled trials (RCTs).
Method
Systematic review and meta-analysis followed by the PRISMA guidelines using the PICO framework and registered in the PROSPERO. A systematic search of five databases was conducted in November 2022 to identify relevant publications. This study included placebo-controlled clinical trials involving patients who underwent surgery, were pregnant or received chemotherapy, and experienced nausea and vomiting symptoms. The risk of bias and quality of evidence were evaluated by RoB2 and GradePro. Statistical analysis was performed in R software.
Results
Three RCTs of PONV, including 155 postoperative patients, and three RCTs of NVP, including 182 pregnancy patients were pooled for statistical analysis. In the case of NVP, peppermint oil has a significant effect after four days based on various scales and questionnaires (standardized mean difference (SMD): -0.37, 95% confidence interval (CI): -0.68; -0.07). In the case of PONV, peppermint oil has a significant effect after 10 minutes based on various scales (SMD; 0.62, 95% CI: -1.07; -0.17).
Conclusion
Our systematic review and meta-analysis revealed that inhalation of peppermint oil had a beneficial effect on reducing nausea and vomiting symptoms in pregnant women. However, in the case of postoperative patients, peppermint inhalation did not show a considerable decrease in the severity of the symptoms.
Funding
The research were funded by the ITM NKFIA TKP2021-EGA-32 and the Semmelweis Fund for Science and Innovation (STIA-OTKA-2022). DG was granted by the Semmelweis 250+ Excellence Fellowship.

University and Doctoral School

Semmelweis University, Doctoral School of Pharmaceutical Sciences

Supervisor

Dezső Csupor, Attila Ványolós

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7466

Start

16:15

End

16:30

Authors (legacy)

Dorottya Gergő1,2, Gantsetseg Garmaa2,3, Andrea Tóth-Mészáros2, Uyen Nguyen Do To2,4, Andrea Harnos5, Péter Hegyi,2,6,7 Rita Nagy2,6,8, András Bánvölgyi9, Attila Ványolós1,2, Dezső Csupor2,6,10
1 Department of Pharmacognosy, Semmelweis University, Budapest
2 Centre for Translational Medicine, Semmelweis University, Budapest
3 Institute of Translational Medicine, Semmelweis University, Budapest
4 András Pető Faculty, Semmelweis University, Budapest
5 Department of Biomathematics and Informatics, University of Veterinary Medicine Budapest, Budapest
6 Institute for Translational Medicine, Medical School, University of Pécs, Pécs
7 Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest
8 Heim Pál National Pediatric Institute, Budapest
9 Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine,
Semmelweis University, Budapest,
10 Institute of Clinical Pharmacy, University of Szeged, Szeged