PhD Scientific Days 2023

Health Sciences - Posters Q

The added value of the gastrointestinal problems, cognition, sleep, tiredness, and diet bolt-on dimensions to the EQ-5D-5L in patients with coeliac disease

Előadó neve

Angyal, Mária Mercédesz, MSc

Neptun code

G3T5LM

Előadó munkahelye

Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University

Előadó telefonszáma

+36305797708

Előadó e-mail címe

angyalmercedesz@gmail.com

Az előadás címe

The added value of the gastrointestinal problems, cognition, sleep, tiredness, and diet bolt-on dimensions to the EQ-5D-5L in patients with coeliac disease

Szerző(k) neve és munkahelye

Mária Mercédesz Angyal 1

1 Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, Budapest
1 Department of Health Policy, Corvinus University of Budapest, Budapest

Bemutatás módja

Poszter

Szekció

Health Sciences - Posters Q

Language of the presentation

English

Preferred session

Health Sciences

Összefoglaló szövege

Introduction: The EQ-5D is one of the most commonly used generic preference-based health-related quality of life measures in the world, which is recommended by the health technology assessment guidelines in more than 20 countries, including Hungary. However, it may not be able to capture some gastrointestinal and extraintestinal symptoms related to celiac disease (CD), therefore additional dimensions ("bolt-on") may improve its validity.
Aim: To test the psychometric properties of the EQ-5D-5L and the following five bolt-ons: gastrointestinal problems (GI), cognition (CO), sleep (SL), tiredness (TI), and diet (DI).
Method: In 2020–2021, a cross-sectional online survey was conducted amongst 312 adult CD patients in Hungary. Patients completed the EQ-5D-5L questionnaire and the five bolt-ons, Gastrointestinal Symptom Rating Scale (GSRS) and the Satisfaction with Life Scale (SWLS) questionnaires. Ceiling effect reduction and linear regressions were used to explore the impact of bolt-ons on EQ Visual Analogue Scale (EQ VAS). Correlations between the five core dimensions and bolt-ons were computed. Known group validity was assessed by examining whether the EQ-5D-5L+bolt-ons were able to discriminate between different health statuses (poor-fair, good, very good-excellent), GSRS tertiles, and SWLS groups.
Results: The ceiling effect decreased from 38.8% to 7.4% when using the EQ-5D-5L+5 bolt-ons. TI led to the highest ceiling reduction (22% absolute reduction). Known-group comparisons confirmed that the bolt-on items improved the discriminatory power of the EQ-5D-5L: GI, TI and SL dimensions improved the discriminatory power by health status, while GI, TI, SL and DI dimensions for GSRS tertiles; and GI, DI, CO, and TI for the SWLS groups (p<0.001). Weak or moderate correlations were found between the bolt-ons and the five core dimensions, with the exception of GI that showed strong correlations with pain/discomfort (PD) (rs=0.51). The GI and CO bolt-ons improved the explanatory power of EQ-5D-5L on EQ VAS (the adjusted R2 increased from 0.41 to 0.44).
Conclusion: Evidence from our study suggests that adding bolt-ons may increase the validity of EQ-5D-5L of patients with CD. The GI and TI bolt-ons performed particularly well in multiple psychometric tests. Further research is needed to explore whether there is any overlap between the GI bolt-on and the PD dimension.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Other university and doctoral school, not listed above

Department of Health Policy, Corvinus University of Budapest

Supervisor

Fanni Rencz, MD, PhD, Habil.

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7469

Start

10:36

End

10:41

Authors (legacy)

Mária Mercédesz Angyal 1

1 Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, Budapest
1 Department of Health Policy, Corvinus University of Budapest, Budapest