PhD Scientific Days 2023

Clinical Medicine - Posters I

Predictors of Pacing-induced Cardiomyopathy

Előadó neve

Dr. Schwertner, Walter

Neptun code

O5YMZL

Előadó munkahelye

Heart and Vascular Center

Előadó telefonszáma

06303058287

Előadó e-mail címe

sch.walterichard@gmail.com

Az előadás címe

Predictors of Pacing-induced Cardiomyopathy

Szerző(k) neve és munkahelye

1 Walter Schwertner, MD, Heart and Vascular Center, Budapest
2 Anett Behon, MD, Heart and Vascular Center, Budapest
3 Eperke Merkel, MD, Heart and Vascular Center, Budapest
4 Boglárka Veres, MD, Heart and Vascular Center, Budapest
5 Luca Kuthi, MD, Heart and Vascular Center, Budapest
6 Richárd Masszi, MD, Heart and Vascular Center, Budapest
7 István Osztheimer, MD, PhD, Heart and Vascular Center, Budapest
8 Levente Molnár, MD, PhD, Heart and Vascular Center, Budapest
9 Endre Zima, MD, PhD, DSc, Heart and Vascular Center, Budapest
10 László Gellér, MD, PhD, DSc, Heart and Vascular Center, Budapest
11 Annamária Kosztin, MD, Phd, Heart and Vascular Center, Budapest
12 Béla Merkely, MD, Phd, Heart and Vascular Center, Budapest

Bemutatás módja

Poszter

Szekció

Clinical Medicine - Posters I

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Background: Around 12-20% of patients with conventional pacemakers (PM) and implantable cardioverter-defibrillators (ICD) may develop heart failure, atrial fibrillation, or a reduction in systolic function due to sustained right ventricular pacing, requiring Cardiac Resynchronization Therapy upgrade. This clinical syndrome is collectively referred to as Pacing-induced Cardiomyopathy (PiCMP).
Purpose: Our study aimed to compare different definitions of PiCMP and assess predictors of this cardiomyopathy.
Methods: In this study, we retrospectively collected data from 678 patients who underwent conventional PM or ICD implantation. Three definitions of PiCMP were assessed. The overall population was followed-up for 4.2 (2.6-6.3) years.
Results: The total patient population was 68.1±12.3 years old, baseline left ventricular ejection fraction (LVEF) was 47.5±14.2%, the prevalence of female sex was 31%, and the ischemic etiology 43.6%. Based on the criterions of Kaye et al., 28% of the patient population have developed PiCMP; 52% according to the criterion of Kiehl et al. and 21% according to the criteria of Khurshid et al. and Kim et al. In general, whichever definition was used to assess the outcome, patients diagnosed with PiCMP had lower rates of the female sex and LVEF but higher rates of ischemic etiology and ventricular arrhythmias (VAs). Using multivariate Cox regression analysis LVEF (HR:0.97; 95% CI:0.96-0.99; p=0.001), left bundle branch block (LBBB) (HR:1.82; 95% CI:1.14-2.90; p=0.013), ischaemic heart disease (HR:1.41; 95% CI:1.04-1.95; p=0.035), VAs (HR:1.48; 95% CI:1.06-2.08; p=0.019) and mineralocorticoid receptor antagonist (MRA) (HR:1.49; 95% CI:1.09-2.13; p=0.027) were independent predictors of patients developing PiCMP.
Conclusion: In this study, patients developing PiCMP were found to be more polymorbid than patients receiving conventional treatment. Our multivariate analysis confirmed LVEF, LBBB, ischemic etiology, VAs, and MRA as independent predictors of PiCMP.
Funding: The research was supported by the New National Excellence Program (ÚNKP-22-3-II-SE-65) and Semmelweis 250+ Excellence Ph.D. Scholarship (EFOP-3.6.3-VEKOP-16-2017-00009). The Ministry of Innovation and Technology also supported this work NRDI Office within the Artificial Intelligence National Laboratory Program (MILAB) (Project no. RRF-2.3.1-21-2022-00004).

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Annamária Kosztin, MD, Phd

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4607

Start

11:36

End

11:41

Authors (legacy)

1 Walter Schwertner, MD, Heart and Vascular Center, Budapest
2 Anett Behon, MD, Heart and Vascular Center, Budapest
3 Eperke Merkel, MD, Heart and Vascular Center, Budapest
4 Boglárka Veres, MD, Heart and Vascular Center, Budapest
5 Luca Kuthi, MD, Heart and Vascular Center, Budapest
6 Richárd Masszi, MD, Heart and Vascular Center, Budapest
7 István Osztheimer, MD, PhD, Heart and Vascular Center, Budapest
8 Levente Molnár, MD, PhD, Heart and Vascular Center, Budapest
9 Endre Zima, MD, PhD, DSc, Heart and Vascular Center, Budapest
10 László Gellér, MD, PhD, DSc, Heart and Vascular Center, Budapest
11 Annamária Kosztin, MD, Phd, Heart and Vascular Center, Budapest
12 Béla Merkely, MD, Phd, Heart and Vascular Center, Budapest