PhD Scientific Days 2023

Mental Health Sciences - Posters N

Association of Serotonergic Polymorphisms With Aggression in ADHD

Előadó neve

Tünde, Sebők-Welker

Neptun code

ITVHFZ

Előadó munkahelye

Research Centre for Natural Sciences

Előadó telefonszáma

+36707416806

Előadó e-mail címe

welker.tunde.eva@ttk.hu

Az előadás címe

Association of Serotonergic Polymorphisms With Aggression in ADHD

Szerző(k) neve és munkahelye

T. É. Sebők-Welker1,2,
Z. Nemoda3,
N. Angyal3,
J. M. Réthelyi4,
N. Bunford1
1 Clinical- and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences
2 Doctoral School of Mental Health Sciences, Semmelweis University
3 Semmelweis University, Institute of Biochemistry and Molecular Biology, Department of Molecular Biology
4 Semmelweis University, Department of Psychiatry and Psychotherapy

Bemutatás módja

Poszter

Szekció

Mental Health Sciences - Posters N

Language of the presentation

English

Preferred session

Mental Sciences

Összefoglaló szövege

Introduction
The importance of the serotonin neurotransmitter system in aggressive and impulsive behaviors is well documented. The serotonin transporter and serotonin autoreceptors (HTR1A and 1B) play a crucial part in determining the synaptic serotonin level. Some of their genetic variants have been shown to affect gene expression, e.g. the promoter region of the HTR1A gene contains a functional polymorphism (-1018C/G, rs6295), whereas the rs13212041 polymorphism in the non-coding region of the HTR1B gene was shown to alter miR-96 binding and its low expression variant was associated with greater anger and hostility.
Aim
The aim of the current study was to assess the association between aggressive/delinquent behaviors and polymorphisms regulating serotonin expression.
Method
315 adolescent subjects from a community group (50.6% male, mean age:15.9 years [SD:1.06 years]) and a clinical ADHD group (73.7% male, mean age:15.6 years [SD:1.1 years]) were carefully phenotyped on a spectrum of impulsive, delinquent and aggressive behaviors through multiple informants: self-, parent- and teacher report questionnaires (Buss-Perry Aggression Questionnaire, Self-Report Delinquency Scale, Youth Self-Report, Disruptive Behavior Disorder Rating Scale). Genotyping was also performed on polymorphisms that affect serotonin levels. HTTLPR serotonin transporter gene (20-23 bp VNTR region), serotonin autoreceptors 1A (rs6295), 1B(rs130058), 2A(rs6311), and the MAOA gene (5’ region 30bp VNTR). Associations between polymorphisms and behavior were assessed separately in the community and clinical subsample.
Results
The most consistent association results showed with aggression and delinquent behavior.
Conclusion
Differences across with and without ADHD groups with regard to associations between genetic polymorphisms and aggressive / delinquent behavior indicate that certain genetic variants may differentially confer risk for affective outcomes, given ADHD status. That findings held across multiple informants suggest results may be robust.
Funding
This work was funded by an MTA Lendület Grant awarded to NB (#LP2018-3/2018) and SE250+ (EFOP-3.6.3-VEKOP-16-2017-00009) fellowship awarded to SWT.

University and Doctoral School

Semmelweis University, Doctoral School of Mental Health Sciences

Other university and doctoral school, not listed above

-

Supervisor

Dr. Bunford Nóra

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7490

Start

10:42

End

10:47

Authors (legacy)

T. É. Sebők-Welker1,2,
Z. Nemoda3,
N. Angyal3,
J. M. Réthelyi4,
N. Bunford1
1 Clinical- and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences
2 Doctoral School of Mental Health Sciences, Semmelweis University
3 Semmelweis University, Institute of Biochemistry and Molecular Biology, Department of Molecular Biology
4 Semmelweis University, Department of Psychiatry and Psychotherapy