PhD Scientific Days 2023

Pharmaceutical Sciences - Posters F

Formulation of Innovative Electrospun Ocular Inserts for the Treatment of Dry Eye Syndrome

Előadó neve

Dr. Adrienn, Kazsoki, PhD

Neptun code

r5cdjv

Előadó munkahelye

University Pharmacy Department of Pharmacy Administration, Semmelweis University

Előadó telefonszáma

+36302060093

Előadó e-mail címe

kazsoki.adrienn@pharma.semmelweis-univ.hu

Az előadás címe

Formulation of Innovative Electrospun Ocular Inserts for the Treatment of Dry Eye Syndrome

Szerző(k) neve és munkahelye

Adrienn Kazsoki1, Fatemeh Heydari2, Romána Zelkó3
1 University Pharmacy Department of Pharmacy Administration, Semmelweis University
2 University Pharmacy Department of Pharmacy Administration, Semmelweis University
3University Pharmacy Department of Pharmacy Administration, Semmelweis University

Bemutatás módja

Poszter

Szekció

Pharmaceutical Sciences - Posters F

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences

Összefoglaló szövege

Introduction: The formulation of nanofiber-based inserts is a relatively new trend in ophthalmic formulation. Innovative polymer-based medical devices can be used to set the drug release kinetics of drug delivery system, which can lead to improved patient adherence through improved bioavailability and reduced dosing frequency.
Aim: The project aimed to formulate, a core-shell type fibrous insert for the treatment of dry eye syndrome by coaxial electrospinning, which is suitable for tear layer replacement, tear film stabilization, and rehydration. A further objective was the morphological characterization and solid phase analysis of the obtained formulations.
Methods: The composite nanofibrous samples were prepared by coaxial electrospinning. Phosphatidylcholine-derivate-based liposomes were formulated by extrusion technique. As the shell part of the composite nanofiber, several lipid-containing liposome-loaded polyvinyl alcohol was chosen and to improve the bioadhesive property poloxamer 407 was added to the system. The core part of the fiber was containing hyaluronic acid and D-panthenol. The liposomes were characterized by size distribution and zeta-potential measurements. The morphology structure of the prepared electrospun sample was studied and solid-state characterization was carried out.
Results: Based on zeta potential and polydispersity index value it can be revealed successful liposome formulation. Liposome-loaded samples were found to be fibrous, thus the presence of liposomes had no negative effect on fiber formation. FT-IR spectra indicate interactions between polymers. The poor fiber-forming ability of hyaluronic acid can be observed, which was improved by the addition of povidon. The two polymeric precursors were found to be suitable for the formation of a composite fibrous system after the addition of polysorbate 80.
Conclusion: The developed electrospun fibrous sheet can be considered a promising candidate for the treatment of dry eye syndrome. Fibrous webs are produced using a continuous, cost-effective, and highly controllable technology that can be fully integrated into modern pharmaceutical manufacturing.
Funding: This project was supported by ÚNKP-22-4-II-SE-29 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund.

University and Doctoral School

Semmelweis University, Doctoral School of Pharmaceutical Sciences

Supervisor

Romána Zelkó

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1195

Start

11:54

End

11:59

Authors (legacy)

Adrienn Kazsoki1, Fatemeh Heydari2, Romána Zelkó3
1 University Pharmacy Department of Pharmacy Administration, Semmelweis University
2 University Pharmacy Department of Pharmacy Administration, Semmelweis University
3University Pharmacy Department of Pharmacy Administration, Semmelweis University