PhD Scientific Days 2023

Clinical Medicine - Posters J

Decreased Serum Level of Soluble PD-L1 in Discoid Lupus Erythematosus, but not in Subacute Cutaneous Lupus Erythematosus

Előadó neve

Dr. Király, Zsófia

Neptun code

II0GG9

Előadó munkahelye

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University

Előadó telefonszáma

+36303851811

Előadó e-mail címe

zsofiakiraly00@gmail.com

Az előadás címe

Decreased Serum Level of Soluble PD-L1 in Discoid Lupus Erythematosus, but not in Subacute Cutaneous Lupus Erythematosus

Szerző(k) neve és munkahelye

Zsófia Király1, Eszter Nagy2, Anikó Kovács1, Bernadett Hidvégi1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
2 Department of Laboratory Medicine, Semmelweis University, Budapest

Bemutatás módja

Poszter

Szekció

Clinical Medicine - Posters J

Language of the presentation

English

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction
Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease with various clinical forms including subtypes of discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE). The altered function of the programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) axis might play a role in CLE pathogenesis.
Aims
We aimed to explore the soluble forms of PD-1 (sPD-1) and PD-L1 (sPD-L1) in subtypes of CLE.
Methods
Enzyme-linked immunosorbent assay was used to measure the levels of sPD-1 and sPD-L1 in serum of 21 DLE, 18 SCLE, 13 SLE patients and 20 healthy controls (HCs). Mann-Whitney U-test was used to detect any significant differences between patient groups and HCs and Spearmann’s rank correlation coefficient to detect any association between clinical activity of skin symptoms and levels of sPD-1/sPD-L1.
Results
Regarding sPD-1 no statistically significant differences were found between DLE and SCLE groups or in comparison with HCs. Concerning sPD-L1, a significantly lower serum level was found in the DLE group compared to SCLE and HC groups (p=0.027 and p=0.009, respectively). No association between clinical activity of skin symptoms and sPD-1/sPD-L1 levels was found.
Conclusion
Alterations of the inhibitory effect of sPD-L1 on T-cell activity might contribute to the pathogenesis of DLE. sPD-1 seems to play marginal role in the pathogenesis of CLE.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Dr. Bernadett Hidvégi

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6011

Start

11:36

End

11:41

Authors (legacy)

Zsófia Király1, Eszter Nagy2, Anikó Kovács1, Bernadett Hidvégi1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest
2 Department of Laboratory Medicine, Semmelweis University, Budapest