PhD Scientific Days 2023

Mental Health Sciences - Posters N

Investigation of cytokine imbalance in schizophrenia, assessment of the possible role of serum cytokine levels in predicting treatment response, prognosis and psychotic relapses

Előadó neve

Dr. Bodnár, Katalin

Neptun code

R40M4C

Előadó munkahelye

Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

Előadó telefonszáma

+36208258527

Előadó e-mail címe

bodnar.katalin@med.semmelweis-univ.hu

Az előadás címe

Investigation of cytokine imbalance in schizophrenia, assessment of the possible role of serum cytokine levels in predicting treatment response, prognosis and psychotic relapses

Szerző(k) neve és munkahelye

Katalin Bodnár, Réka Zsigmond, Levente Hermán, János Réthelyi
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Mental Health Sciences - Posters N

Language of the presentation

Hungarian

Preferred session

Mental Sciences

Összefoglaló szövege

Schizophrenia, a multisystem chronic psychiatric disorder of unknown etiology, is associated with several immune dysfunctions, including abnormal levels of circulating cytokines. Exsisting evidence shows a potential causative role for cytokines in schizophrenia symptom development. Furthermore, disease duration, symptom severity, aggressive behavior, and cognitive deficits are correlated with levels of certain cytokines. In this study, we recruit chronic schizophrenia patients who are hospitalized due to a psychotic relapse. We investigate cytokine levels, blood samples are taken on hospital admission, in the 6th and 12th weeks and 6 months after the relapse. Based on the publications, we mainly focus on the Il-2, Il-4, Il-6 and Il-10 levels, which can serve as possible predictive biomarkers relating to treatment response. We will also assess the possible role of abnormal cytokine levels and their association with symptoms severity and their potential clinical implications. The severity of the symptoms is monitored with the PANSS and we test the change in the patients' quality of life with the Lancashire scale. The effect of antipsychotic treatment on the immune system is also unclear, the studies have different results. Therefore, in patients included in our study, we also investigate whether there is a correlation between cytokine levels and the therapeutic response to antipsychotics, by measuringe blood antypsychotics levels at the above times. A better understanding of cytokine imbalance in schizophrenia patients can potentially help in early diagnosis, novel therapeutic target indentification and development, patient stratification for choosing the best therapeutic protocol, and predicting prognosis, relapse and treatment response.
Keywords: cytokine, immune system, schizophrenia, interleukin
E-mail: bodnar.katalin@med.semmelweis-univ.hu
University: Semmelweis University, Budapest
Doctoral School: Mental Health Sciences, Psychiatry Program

University and Doctoral School

Semmelweis University, Doctoral School of Mental Health Sciences

Supervisor

János Réthelyi

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7498

Start

10:54

End

10:59

Authors (legacy)

Katalin Bodnár, Réka Zsigmond, Levente Hermán, János Réthelyi
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary