PhD Scientific Days 2023
Budapest, 22-23 June 2023
Clinical Medicine - Posters J
Dermoscopy-guided High-frequency Ultrasound Can Differentiate Aggressive Histological Subtypes of Basal Cell Carcinoma
Előadó neve
Dr. Kiss, Norbert
Neptun code
-
Előadó munkahelye
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University
Előadó telefonszáma
+36206701698
Előadó e-mail címe
kiss.norbert@med.semmelweis-univ.hu
Az előadás címe
Dermoscopy-guided High-frequency Ultrasound Can Differentiate Aggressive Histological Subtypes of Basal Cell Carcinoma
Szerző(k) neve és munkahelye
Norbert Kiss1, Szabolcs Bozsányi1, Klára Farkas1, Phyllida Hamilton-Meikle1, Boglárka Szabó1, Flóra Vasanits1, Lili Gulyás1, Noémi Nóra Varga1, Kende Lőrincz1, György Paragh2, Péter Holló1, Norbert M. Wikonkál1 and András Bánvölgyi1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
2 Department of Dermatology and Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA
Bemutatás módja
Poszter
Szekció
Clinical Medicine - Posters J
Language of the presentation
English
Preferred session
Clinical Medicine
Összefoglaló szövege
Introduction: Basal cell carcinoma (BCC) risk is mostly defined by tumor location, size, and histological subtype (HST). Location and size are evident at the time of diagnosis but establishing HST currently relies on invasive biopsy or excision of the tumor. Superficial and nodular BCCs behave more indolently, while infiltrative, micronodular, and morpheaform BCCs are aggressive and show greater subclinical extension and recurrence risk. Thus, BCC HST drives treatment decision-making. Low-risk BCCs can be effectively treated with local destructive or topical therapies, while high-risk HST require surgical removal.
Aims: We aimed to assess whether in vivo dermoscopy guided high-frequency ultrasound (DG-HFUS) imaging can identify BCCs with aggressive HST and thus may aid early treatment planning.
Method: We performed a clinical and dermoscopic examination of BCCs followed by 33 MHz DG-HFUS imaging, surgical excision, and histological examination at the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University.
Results: 52 patients with BCC were enrolled, with a mean age of 72.6±10.9 years. Histology established 13 lesions as aggressive HST (infiltrative or micronodular subtype) and 39 as low-risk HST (superficial or nodular subtype). With DG-HFUS, aggressive BCC HSTs could be distinguished from low-risk HST based on their irregular shape (p<0.0001), ill-defined margins (p<0.0001), and non-homogeneous internal echoes (p=0.004) upon statistical analysis with Fisher's exact test. Using on novel scoring system based on these criteria, DG-HFUS differentiated aggressive HSTs from low-risk with higher sensitivity (84.6%) and specificity (92.3%) than macroscopic and dermoscopic evaluation (sensitivity: 31.9%, specificity: 75.5%).
Conclusion: Based on our results, DG-HFUS can distinguish aggressive BCC subtypes from low-risk HSTs using easily identifiable morphological parameters and may support early therapeutic decision-making.
Funding: This work was supported by the ÚNKP-22-4-II-SE-13 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (N.K.).
University and Doctoral School
Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine
Supervisor
-
Publication of my abstract
I do not give consent to the publication of my abstract on the website of the congress.
Kind
Szabad
Status
elfogadva
Accepted presentation method
poszter
Előadás fájl jóváhagyás
nem rendelkezett róla
Előadó
4113
Start
11:42
End
11:47
Authors (legacy)
Norbert Kiss1, Szabolcs Bozsányi1, Klára Farkas1, Phyllida Hamilton-Meikle1, Boglárka Szabó1, Flóra Vasanits1, Lili Gulyás1, Noémi Nóra Varga1, Kende Lőrincz1, György Paragh2, Péter Holló1, Norbert M. Wikonkál1 and András Bánvölgyi1
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
2 Department of Dermatology and Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA