PhD Scientific Days 2023

Mental Health Sciences IV.

Microstructural Differences in Migraine: a Diffusion-Tensor Imaging Study

Előadó neve

Dobos, Dóra, PhD

Neptun code

AZG05Q

Előadó munkahelye

Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University

Előadó telefonszáma

+36304256112

Előadó e-mail címe

dobos.dora@semmelweis-univ.hu

Az előadás címe

Microstructural Differences in Migraine: a Diffusion-Tensor Imaging Study

Szerző(k) neve és munkahelye

D. Dobos1,2,3, G. Kökönyei1,2,3,4, G. Gyebnár5, K. Gecse1,2,3, E. Szabó2,4,6,7, D. Baksa1,2,3, N. Kocsel2,4, A. Galambos2,4, T. Zsombók2, L. R. Kozák5, G. Juhász1,2,3
1 NAP3.0- SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest.
2 SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest.
3 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest.
4 Institute of Psychology, ELTE Eötvös Loránd University, Budapest.
5 Magnetic Resonance Research Centre, Semmelweis University, Budapest.
6 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston.
7 Department of Anesthesia, Harvard Medical School, Boston.

Bemutatás módja

Szóbeli

Szekció

Mental Health Sciences IV.

Language of the presentation

Hungarian

Preferred session

Mental Sciences

Összefoglaló szövege

Introduction: Microstructural alterations in migraine sufferers have been reported by several studies, but with inconsistencies. Brain tissue integrity (BTI) can be described with fractional anisotropy (FA) indexing the directionality of water diffusion and mean diffusivity (MD) reflecting the amplitude of water diffusion.
Aims: To test whether the BTI of subjects suffering from episodic migraine without aura (MwoA) differ from the BTI of control subjects and to check whether migraine features correlate with FA or MD values in MwoA.
Methods: Diffusion-MRI data of 37 subjects with migraines (female=30) and 40 healthy controls (female=25) were collected. FA and MD were calculated and entered in a between-group analysis in SPM12 using age and sex as covariates. Results surviving family-wise error correction (pFWE<0.05) were considered statistically significant. In addition, self-reported migraine parameters were correlated with mean FA and MD values.
Result: In MwoA, higher FA was found in thirteen clusters including the cerebellum, temporal and frontal lobes, left postcentral gyrus, right precentral gyrus, angular gyrus, and paracingulate cortex, while lower FA in five clusters: paracentral lobule, occipital lobe, fusiform gyrus, angular gyrus, and precuneus. MD was increased in the cerebellum and brainstem in controls vs. MwoA, but no significant voxel was found in the MwoA>Controls contrast. Migraine duration positively correlated with FA values in the frontal pole and medial frontal cortex (ρ=0.48, p=0.0032), but negatively in the superior parietal lobule (ρ=-0.35, p=0.0391).
Conclusion: Dysfunction of frontal regions is often linked to migraine chronification. As our subjects with longer migraine duration remained episodic, a positive correlation with the integrity of frontal regions may indicate a protective function of this area. The superior parietal lobule is next to the superior longitudinal fasciculus associated with vestibular function, which is impaired in migraine. Thus, the loss of integrity with duration is plausible. Altered microstructure in migraine indicates neural changes either preventing or promoting chronification.
Funding:
NAP2022-I-4/2022; 2017-1.2.1-NKP-2017-00002; KTIA_13_NAPA-II/14; KTIA_NAP_13-1-2013-0001; KTIA_NAP_13-2- 2015-0001; 2020-4.1.1.-TKP2020; TKP2021-EGA-25; 2019-2.1.7-ERA-NET-2020-00005; ÚNKP-22-3-II-SE-17.

University and Doctoral School

Semmelweis University, Doctoral School of Mental Health Sciences

Supervisor

Dr. Juhász Gabriella

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5971

Start

15:00

End

15:15

Authors (legacy)

D. Dobos1,2,3, G. Kökönyei1,2,3,4, G. Gyebnár5, K. Gecse1,2,3, E. Szabó2,4,6,7, D. Baksa1,2,3, N. Kocsel2,4, A. Galambos2,4, T. Zsombók2, L. R. Kozák5, G. Juhász1,2,3
1 NAP3.0- SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest.
2 SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest.
3 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest.
4 Institute of Psychology, ELTE Eötvös Loránd University, Budapest.
5 Magnetic Resonance Research Centre, Semmelweis University, Budapest.
6 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston.
7 Department of Anesthesia, Harvard Medical School, Boston.