PhD Scientific Days 2023

KDP Poster session

Prophylactic versus clinically-driven antibiotics after successful resuscitation: a systematic review and meta-analysis

Előadó neve

Dr. Boldizsar, Kiss

Neptun code

BMSOE5

Előadó munkahelye

Semmelweis University, Heart and Vascular Centre

Előadó telefonszáma

+36 20 6663575

Előadó e-mail címe

b.kiss96@gmail.com

Az előadás címe

Prophylactic versus clinically-driven antibiotics after successful resuscitation: a systematic review and meta-analysis

Szerző(k) neve és munkahelye

Boldizsár Kiss1,2, Boglárka Veres1,2, Rita Nagy2,3,4, Péter Fehérvári2, Péter Hegyi2,4, Endre Zima1
1 Heart and Vascular Centre, Semmelweis University, Budapest, Hungary
2 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
3 Heim Pál National Pediatric Insitute, Budapest, Hungary
4 Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

KDP Poster session

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction
Early onset-pneumonia is a frequent infectious complication after resuscitation, due to potential aspiration during the resuscitation and airway management, or immunological impairment. There is few available data whether early timing of antibiotics could efficiently reduce the risk of any type of infectious complication.
Aims
Our aim is to compare the effect of prophylactic antibiotics compared with clinically driven antibiotics on infection related outcomes.
Methods
Our systematic search was conducted on the December 1st, 2021 in five databases: Medline, Embase, Cochrane, Scopus and Web of Science. The patient population was adult patients admitted to intensive care unit after successful resuscitation in any setting. We included all studies that compared prophylactic and clinically-driven antibiotic administration after resuscitation in this population without any restriction concerning about the type of antibiotics. The primary outcome was the incidence of pneumonia, mortality and neurological outcome. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated. Randomized controlled trials (RCT) and observational studies were included. The statistical analysis was performed by R software.
Results
5623 records were identified and 16 met the selection criteria and were included in the qualitative analysis. Out of these, 15 studies (5 RCTs, 10 observational) were included in the quantitative synthesis. Prophylactic antibiotic administration was not associated with lower incidence of pneumonia (OR 0.67, 95% CI 0.33-1.34), mortality rate (OR 1.05, 95% CI 1.36), higher rate of good neurological outcome (OR 1.84, 95% CI 0.50-6.79). Our results were consistent for both the observational and randomized subgroups as well.
Conclusion
Prophylactic antibiotic was not associated with an improvement in any important clinical outcome. Current data and analysis does not support prophylactic antibiotic usage in patients following cardiac arrest. More randomized trials should address this important clinical question.
Funding
BK was supported by grant EFOP-3.6.3-VEKOP-16-2017-00009.

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Prof. Dr. Endre Zima

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7519

Start

09:12

End

09:17

Authors (legacy)

Boldizsár Kiss1,2, Boglárka Veres1,2, Rita Nagy2,3,4, Péter Fehérvári2, Péter Hegyi2,4, Endre Zima1
1 Heart and Vascular Centre, Semmelweis University, Budapest, Hungary
2 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
3 Heim Pál National Pediatric Insitute, Budapest, Hungary
4 Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary