PhD Scientific Days 2023

Clinical Medicine - Posters A

Coronary CT-based FFR in patients with acute myocardial infarction may predict follow-up invasive FFR.

Előadó neve

Dr. Boussoussou, Melinda

Neptun code

IMK4SC

Előadó munkahelye

Semmelweis University Heart and Vascular Center

Előadó telefonszáma

06206632859

Előadó e-mail címe

melinda.b.md@gmail.com

Az előadás címe

Coronary CT-based FFR in patients with acute myocardial infarction may predict follow-up invasive FFR.

Szerző(k) neve és munkahelye

Semmelweis University Heart and Vascular Center

Bemutatás módja

Poszter

Szekció

Clinical Medicine - Posters A

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Background: We aimed to evaluate whether invasive fractional flow reserve (FFRi) of non-infarction related (non-IRA) lesions changes over time in ST-elevation myocardial infarction (STEMI) patients. Moreover, we assessed the diagnostic performance of coronary CT angiography-derived FFR (FFR-CT) following the index event in predicting follow-up FFRi.
Methods: We prospectively enrolled 38 STEMI patients (mean age 61.6±9 years, 23.1% female) who underwent non-IRA baseline and follow-up FFRi measurements and a baseline FFR-CT (within ≤10 days after STEMI). Follow-up FFRi was performed at 45-60 days (FFRi and FFR-CT value of ≤0.8 was considered positive)
Results: FFRi values showed a significant difference between baseline and follow-up (median and interquartile range (IQR) 0.85[0.78-0.92] vs. 0.81[0.73-0.90] p=0.04, respectively). Median FFRCT was 0.81[0.68-0.93]. In total, 20 lesions were positive on FFR-CT. A stronger correlation and smaller bias were found between FFR-CT and follow-up FFRi (ρ=0.86,p<0.001,bias:0.01) as compared with baseline FFRi (ρ=0.68, p<0.001,bias:0.04). Comparing follow-up FFRi and FFR-CT, no false negatives but two false positive cases were found. The overall accuracy was 94.7%, with sensitivity and specificity of 100.0% and 90.0% for identifying lesions ≤0.8 on FFRi. Accuracy, sensitivity, and specificity were 81.5%, 93.3% 73.9%, respectively, for identifying significant lesions on baseline FFRi using index FFR-CT.
Conclusion: FFR-CT in STEMI patients close to the index event could identify hemodynamically relevant non-IRA lesions with higher accuracy than FFRi measured at the index PCI, using follow-up FFRi as the reference standard. Early FFR-CT in STEMI patients might represent a new application for cardiac CT to improve the identification of patients who benefit most from staged non-IRA revascularization.
Fundng: ÚNKP-22-3-II-SE-51, New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation fund.
Project no. NVKP_16-1–2016-0017 (’National Heart Program’) has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the NVKP_16 funding scheme.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

Dr. Maurovich-Horvat Pál

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4775

Start

11:36

End

11:41

Authors (legacy)

Semmelweis University Heart and Vascular Center