PhD Scientific Days 2023

Translational Medicine II.

Polymer nanocomposites development for wound healing applications

Előadó neve

Dr. Voniatis, Constantinos

Neptun code

o6vp8p

Előadó munkahelye

Department of Biophysics and Radiation Biology

Előadó telefonszáma

+36208258954

Előadó e-mail címe

constantinosvoniatis@gmail.com

Az előadás címe

Polymer nanocomposites development for wound healing applications

Szerző(k) neve és munkahelye

Constantinos Voniatis, Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology.
Kenigen Manikion, Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology.
Angéla Jedlovszky-Hajdú, Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology.

Bemutatás módja

Szóbeli

Szekció

Translational Medicine II.

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: The development of tissue engineering scaffolds has become an attractive subject in the biomedical and biotechnological fields, with the ultimate aim of finding the appropriate correlation between biocompatibility, biodegradability and functionality that promotes and improves tissue regeneration. Nanofibrous scaffolds have a key role in tissue engineering. However, it is not easy to find the optimal balance between physical and chemical properties. As a result, composite materials have been used in many fields of bioengineering because they provide advantages of two or more materials. Polylactic acid (PLA) is a popularly used biodegradable polymer however its disadvantages, such as rigidity and hydrophobicity which makes cell adhesion limited. The addition of polysuccinimide (PSI), a versatile, easy to functionalise polymer, could solve these issues.

Aim: The objective was to fabricate a composite, fibrous mesh that would have the ideal biological and mechanical properties that will enhance tissue regeneration.

Method: To achieve our target, we co-electrospun polysuccinimide/ polylactic acid (PSI/PLA) meshes. The meshes obtained were used for chemical, physical and mechanical evaluation.

Results: After successful fabrication of the composite meshes, a scanning electron microscope analysis was performed. No structural aberrations or artefacts were found. Average diameters of the fibers were also measured: PSI= 550 ±120 nm, PLA= 630 ± 230 nm, PSI/PLA= 580 ±143 nm. We were able to confirm the presence of both materials using ATR FTIR. The mechanical measurements showed a higher loading capacity for PSI than PLA but the combination of the materials demonstrated a specific loading capacity even higher exhibit a synergistic effect. Lastly, the water contact angle was estimated, and the PSI component was able to significantly decrease the hydrophobicity of PLA.

Conclusion: The combination of PSI/PLA in the composite mesh showed greater strength than individual materials. Furthermore, we have also documented an increase in hydrophilicity that could lead to better cell penetration, so the composite network shows great potential in tissue engineering.

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Dr. Angéla Jedlovszky-Hajdú

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4727

Start

13:00

End

13:15

Authors (legacy)

Constantinos Voniatis, Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology.
Kenigen Manikion, Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology.
Angéla Jedlovszky-Hajdú, Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology.