PhD Scientific Days 2023

Clinical Medicine - Posters I

The risk factors of acute pancreatitis progression into recurrent acute pancreatitis and chronic pancreatitis. A systematic review and meta – analysis.

Előadó neve

Dr. Gagyi, Endre-Botond

Neptun code

F7RIFK

Előadó munkahelye

Center for Translational Medicine

Előadó telefonszáma

+36308693145

Előadó e-mail címe

endre.gg@gmail.com

Az előadás címe

The risk factors of acute pancreatitis progression into recurrent acute pancreatitis and chronic pancreatitis. A systematic review and meta – analysis.

Szerző(k) neve és munkahelye

authors: Endre - Botond Gagyi1,2, Mahmoud Obeidat1,3, Edina Tari1,6, Szilárd Váncsa1,3,6, Dániel Sándor Veres1,4, Banovcin Peter5, Péter Jenő Hegyi1,3,6, Péter Hegyi1,3,6 , Bálint Erőss1,3,6
1. Center for Translational Medicine, Semmelweis University, Budapest, Hungary
2. Selye János Doctoral College for Advanced Studies, Semmelweis University, Budapest, Hungary
3. Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
4. Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary
5. Gastroenterology Clinic, University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
6. Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Clinical Medicine - Posters I

Language of the presentation

English

Preferred session

Clinical Medicine

Összefoglaló szövege

Aim: This systematic review and meta-analysis aimed to identify risk factors associated with this progression.
Methods: The protocol was registered on PROSPERO (CRD42022368931). A comprehensive search was conducted in three (Medline, Embase, Cochrane) databases on October 25th, 2022. Articles reporting AP – RAP or RAP – CP patient groups comparisons and risk factors associated with AP progression into RAP or CP were included. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model. Heterogeneity was evaluated using the I² statistic. The risk of bias assessment was performed using the Quality in Prognostic Studies (QUIPS) tool.
Results: A total of 71 articles were included in the meta–analysis, and several risk factors were identified for the progression of AP into RAP and CP. We found the following risk factors of AP recurrence: younger age, male gender, smoking, alcoholic etiology, hypertriglyceridemia, diabetes mellitus, pseudocyst, etc. The pooled OR for the male gender was 1.45 (95% CI: 1.29-1.64, I²=24%), for smoking was 1.45 (95% CI: 1.16-1.81, I²=62%), for alcoholic etiology was 1.76 (95% CI: 1.38-2.25, I²=81%), for hypertriglyceridemia was 2.45 (95% CI: 2.07-2.90, I²=9%), for diabetes mellitus was 1.49 (95% CI: 1.24-1.80, I²=0%), for pseudocyst was 2.19 (95% CI: 1.52-3.15, I²=0%). We also found risk factors of RAP progression into CP, which were the following: male gender, alcoholic etiology, alcohol consumption, smoking, etc. The risk of bias was moderate in the majority of the included studies.
Conclusion: Our study identified multiple modifiable risk factors which can be treated to prevent the progression of pancreatitis.
Funding: None to declare.

University and Doctoral School

Semmelweis University, Doctoral School of Pharmaceutical Sciences

Supervisor

Erőss Bálint

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7361

Start

10:42

End

10:47

Authors (legacy)

authors: Endre - Botond Gagyi1,2, Mahmoud Obeidat1,3, Edina Tari1,6, Szilárd Váncsa1,3,6, Dániel Sándor Veres1,4, Banovcin Peter5, Péter Jenő Hegyi1,3,6, Péter Hegyi1,3,6 , Bálint Erőss1,3,6
1. Center for Translational Medicine, Semmelweis University, Budapest, Hungary
2. Selye János Doctoral College for Advanced Studies, Semmelweis University, Budapest, Hungary
3. Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
4. Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary
5. Gastroenterology Clinic, University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
6. Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary