PhD Scientific Days 2024

Poster Session N - Cardiovascular Medicine and Research 2.

Pressure-strain-volume loop-derived myocardial work for the noninvasive assessment of increased right ventricular contractility in elite athletes

Előadó neve

Dr. Fábián, Alexandra, PhD

Neptun code

CDN6SP

Előadó munkahelye

Semmelweis University Heart and Vascular Center

Előadó telefonszáma

06209838298

Előadó e-mail címe

f.ala934@gmail.com

Az előadás címe

Pressure-strain-volume loop-derived myocardial work for the noninvasive assessment of increased right ventricular contractility in elite athletes

Szerző(k) neve és munkahelye

Alexandra Fábián¹, Adam Szijarto¹, Adrienn Ujvari¹, Bálint K. Lakatos¹, Marton Tokodi¹, Zsuzsanna Ladányi¹, Andrea Ferencz¹, Mate Tolvaj¹, Kai Shiida¹, Orsolya Kiss¹, Nóra Sydó¹, Hajnalka Vágó¹, Prof. Béla Merkely¹, Attila Kovacs¹

1: Semmelweis University Heart and Vascular Center

Bemutatás módja

Poszter

Szekció

Poster Session N - Cardiovascular Medicine and Research 2.

Language of the presentation

English

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Background: Regular, intense exercise results in increased right ventricular (RV) contractility, however, conventional resting echocardiographic metrics cannot capture intrinsic contractile state accurately. Thus, we aimed to develop a novel method to quantify RV function independently of hemodynamic loading conditions and to assess its relationship with exercise capacity in elite athletes.

Methods: Elite athletes (n=269) and sedentary volunteers (n=26) were enrolled and underwent 3D echocardiography (3DE) to measure RV volumes and ejection fraction (EF). 3DE-derived global longitudinal strain (GLS) tracings and non-invasively estimated RV pressure curves were concatenated to calculate global myocardial work index (GMWI). Then, GMWI was adjusted to instantaneous RV volumes (GMWIV), and pressure-strain-volume loops were plotted.

Results: Athletes had lower resting RV EF (55±5 vs. 60±5%; p<0.01), and GLS (-22±3 vs. -23±4%, p<0.05), whereas GMWI did not differ. Athletes had higher values of GMWIV (3436±1360 vs. 2375±813 mmHg%·mL, p<0.01). GMWIV correlated better with cardiopulmonary exercise testing-derived peak oxygen uptake (r=0.57, p<0.01), than RV EF (r=-0.39, p<0.01) and GLS (r=0.25, p<0.01), whereas GMWI did not correlate.

Conclusion: By integrating RV volume into the pressure-strain relationship, our novel metric could adequately reflect enhanced RV function in athletes even during resting conditions. Moreover, our metric showed good correlation with exercise capacity.

Funding: The project was supported by the ÚNKP-23-4-II-SE-37 New National Excellence Program of the Ministry for Innovation and Technology.

University

Semmelweis University

Supervisor

Attila Kovács MD, PhD

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5932

Start

16:05

End

16:08