PhD Scientific Days 2024

Conservative Medicine

Cardiovascular Risk Evaluation of Moderate-to-Severe Psoriatic Patients

Előadó neve

Ms. Kolonics, Mária Veronika

Neptun code

C0CJX4

Előadó munkahelye

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University

Előadó telefonszáma

+36309776619

Előadó e-mail címe

mv.kolonics@gmail.com

Az előadás címe

Cardiovascular Risk Evaluation of Moderate-to-Severe Psoriatic Patients

Szerző(k) neve és munkahelye

Mária Veronika Kolonics¹, Éva Anna Piros MD, PhD¹, Noémi Ágnes Galajda MD², Andrea Lukács MD¹, Bernadett Hon-Balla MD², Borbála Vattay MD³, Bálint Szilveszter MD, PhD⁴, Fanni Rencz MD, PhD⁵, Ákos Szabó⁵, Péter Holló MD, PhD⁶

1: Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085
2: Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085, Károly Rácz Conservative Medicine Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary
3: Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary, Károly Rácz Conservative Medicine Division, Doctoral College, Semmelweis University, 1091 Budapest, Hungary
4: Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary
5: Department of Health Economics, Corvinus University, 1093 Budapest, Hungary
6: Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary

Bemutatás módja

Szóbeli

Szekció

Conservative Medicine

Language of the presentation

English

Preferred session

Conservative Medicine

Összefoglaló szövege

Introduction: Psoriasis is one of the most common autoinflammatory skin diseases with a world prevalence of 2-3%. The generalized inflammation caused by psoriasis may have an effect not only on the skin and joints but also on the cardiovascular (CV) system. Psoriasis considered to be an independent CV risk factor: the incidence of myocardial infarction is three times higher, while the life expectancy is 5 years shorter in this patient group.

Aims: Our aim was to conduct a detailed CV risk stratification by using widely known CV risk estimating calculators, routine laboratory examinations and medical imaging procedures to detect easily approachable parameters to predict CV involvement of moderate-to-severe psoriatic patients without any cardiac complaints.

Method: 44 moderate-to-severe psoriatic patients treated with IL-17 or IL-23 inhibitor therapy were enrolled from the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University. Obligatory inclusion criteria were the lack of cardiac complaints, negative ECG and negative echocardiography. Calcium scoring was assessed on native coronary CT, peripheral arterial intima-media measurements were taken using 2D linear ultrasound and further routine laboratory tests were conducted. According to the results of calcium scoring, high (CACS>0) and low (CACS=0) CV risk cohorts were set for further analysis. Calcium score values were compared to non-psoriatic, matched controls. Three validated, widely used CV risk calculators were applied.

Results: The calcium scoring detected significantly higher CACS values in the psoriatic cohort compared to non-psoriatic controls. In the high CV risk group higher disease activity, elevated levels of unfavorable, pro-atherogenic laboratory markers and greater CV risk scores were observed. In the low CV risk (CACS=0) cohort no calcified peripheral plaques were detected. All three risk calculators showed significantly higher CV risk in the high risk (CACS>0) cohort.

Conclusion: According to our results, the lack of cardiac complaints is not equal to low CV risk in the moderate-to-severe psoriatic population. The everyday use of CV risk estimating tools in dermatological practice would be needed to detect cardiologically affected but asymptomatic psoriatic patients.

Funding: none

University

Semmelweis University

Supervisor

Prof. Péter Holló

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7995

Start

11:30

End

11:40