PhD Scientific Days 2024

Theoretical and Translational Medicine I.

Synergistic properties of polysuccinimide/poly(lactic acid) co-electrospun and blended-electrospun nanofibres

Előadó neve

Mr. Manikion, Kenigen

Neptun code

L3ZZ27

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36703948480

Előadó e-mail címe

kenigen.manikion33@gmail.com

Az előadás címe

Synergistic properties of polysuccinimide/poly(lactic acid) co-electrospun and blended-electrospun nanofibres

Szerző(k) neve és munkahelye

Kenigen Manikion¹, Constantinos Voniatis¹, Gergö Gyulai², Angela Jedlovszky-Hajdu¹

1: Semmelweis University
2: Eötvös Loránd University

Bemutatás módja

Szóbeli

Szekció

Theoretical and Translational Medicine I.

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Integrating surgical implants in a biological host is an essential but challenging task in regenerative medicine. If implants do not support proper cell adhesion, infiltration, and migration, the immune system can respond by forming a fibrous capsule around it, isolating and rendering it ineffective. To overcome this obstacle, researchers are exploring blend and composite materials. Poly (lactic acid) (PLA) is popular in biomedical applications for its biocompatibility, chemical stability, and affordability, despite its hydrophobic nature, poor cell adhesion, and slow degradation rate. Polysuccinimide (PSI), on the other hand, is renowned for its superior cell adhesion, biocompatibility, and quick degradation.
Our goal was to fabricate an electrospun mesh incorporating both a fast-degrading (PSI) and a slow-degrading (PLA) component using different electrospinning set-ups.
We used co-electrospinning and blend-electrospinning techniques to produce polysuccinimide/polylactic acid (PSI/PLA) meshes, which were then subjected to chemical, physical, and mechanical characterisation.
The meshes were successfully produced, with scanning electron microscopy confirming no structural defects. While the co-electrospun meshes were flat, the blend-electrospun meshes exhibited a three dimensional structure. Fiber diameters averaged 580 ± 140 nm for co-electrospun and 650 ± 110 nm for blend-electrospun meshes. ATR-FTIR analysis confirmed the presence of both materials. Compared to pure PLA meshes, the co-electrospun meshes showed increased hydrophilicity and higher specific loading capacity. On the other hand, the blend meshes underperformed. The in vitro degradation test revealed that the PSI component degrades within a week, whereas the PLA component remained stable for over four weeks.
The co-electrospun PSI/PLA meshes showed enhanced strength, suggesting a synergistic relationship compared to the blend-electrospun meshes, which performed poorly but exhibited a three dimensional structure. The improved hydrophilicity in the co-electrospun meshes indicates potential for better cell adhesion. It was clear that PSI degrades much faster than PLA. Both meshes can be used for different applications according to their advantages.

University

Semmelweis University

Supervisor

Dr. Voniatis Constantinos

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8104

Start

10:15

End

10:25