PhD Scientific Days 2024

Poster Session D - Neurosciences 1.

Revealing a Novel Pontine Reward Center in Mammals

Előadó neve

Dr. Zichó, Krisztián

Neptun code

AY9H43

Előadó munkahelye

Laboratory of Cerebral Cortex Research, HUN-REN Institute of Experimental Medicine, Budapest, Hungary

Előadó telefonszáma

+36303648093

Előadó e-mail címe

zicho.krisztian@koki.hu

Az előadás címe

Revealing a Novel Pontine Reward Center in Mammals

Szerző(k) neve és munkahelye

Krisztián Zichó¹, Boldizsár Zsolt Balog², Réka Z. Sebestény², Charlotte Seng³, Áron Orosz², Manó Aliczki⁴, Eva Mikics⁴, Csaba Földy³, Gábor Nyiri²

1: HUN-REN Kísérleti Orvostudományi Kutatóintézet
2: Laboratory of Cerebral Cortex Research, HUN-REN Institute of Experimental Medicine, Budapest, Hungary
3: Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich, Switzerland
4: Laboratory of Translational Behavioral Neuroscience, HUN-REN Institute of Experimental Medicine, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session D - Neurosciences 1.

Language of the presentation

English

Preferred session

Neurosciences

Összefoglaló szövege

Rewards are vital for motivation, decision-making, memory, and mental health. Using viral tract tracing, immunohistochemistry, light- and fluorescent microscopic imaging, fiber photometry recording and optogenetic behavioral experiments in transgenic mice, we investigated a previously unrecognized gamma-aminobutyric acid (GABA)-ergic cell population in the pons that we named the subventricular tegmental nucleus (SVTg). These SVTg neurons localized beneath the fourth ventricle and establish inhibitory synapses in LHb, a brain center involved in aversion and depression. SVTg neurons were activated by rewarding and reward-predicting experience. Mice self-stimulated SVTg neurons, suggesting its role in reward-seeking behavior. Furthermore, we found that special AT-rich sequence-binding protein-1 (Satb1) is a highly specific marker of these SVTg neurons. Therefore, using Satb1 immunohistochemistry, we could locate the SVTg under the fourth ventricle in the pontine central grey both in rat, in rhesus macaque monkeys and in humans. Our results suggest that a GABAergic pontine nucleus (SVTg) has a major role in reward processing shedding new light on a fundamental brain mechanism and potentially providing a therapeutic target for mood disorders.
Funding: This project was supported by the ÚNKP-23-3-II-SE-24 New National Excellence Program of the Ministry of Innovation, by the EFOP-3.6.3-VEKOP-16-2017-00009 Semmelweis 250+ Excellence PhD Fellowship and sponsored by Gedeon Richter Talentum Foundation in framework of Gedeon Richter Excellence PhD Scholarship of Gedeon Richter.

University

Semmelweis University

Supervisor

Gábor Nyiri

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5982

Start

15:00

End

15:03