PhD Scientific Days 2024

Poster Session O - Surgical Medicine

Comparative Analysis of Radical Surgical and Bladder-preserving Therapy for Limited Stage Small Cell Bladder Cancer: A Systematic Review and Meta-Analysis

Előadó neve

Dr. Kubik, András

Neptun code

NJ5WXI

Előadó munkahelye

Semmelweis University, Department of Urology

Előadó telefonszáma

+36206663430

Előadó e-mail címe

kubik.andras@semmelweis.hu

Az előadás címe

Comparative Analysis of Radical Surgical and Bladder-preserving Therapy for Limited Stage Small Cell Bladder Cancer: A Systematic Review and Meta-Analysis

Szerző(k) neve és munkahelye

András Kubik^1,2, Isabel Pinto Amorim das Virgens², Nóra Varga³, Anett Szabó^1,2, Attila Keszthelyi¹, Péter Fehérvári^2,4, Péter Hegyi^2,5,6, Nándor Ács^2,7, Péter Nyirády¹, Tibor Szarvas^1,8

1: Department of Urology, Semmelweis University, Budapest, Hungary
2: Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
3: Semmelweis University, Budapest, Hungary
4: Department of Biostatistics, University of Veterinary Medicine, Budapest, Hungary
5: Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
6: Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary
7: Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
8: Department of Urology, University of Duisburg-Essen and German Cancer Consortium (DKTK) - University Hospital Essen, Essen, Germany

Bemutatás módja

Poszter

Szekció

Poster Session O - Surgical Medicine

Language of the presentation

English

Preferred session

Surgical Medicine

Összefoglaló szövege

Background: Currently, radical surgery and chemotherapy are the gold standard treatments for patients with small-cell bladder cancer (SCBC); however, the optimal treatment is still debated. Therefore, our aim was to compare the overall survival (OS) of non-metastatic, limited stage (LS) SCBC patients who underwent radiation-based multimodal therapy (RBMMT) vs. cystectomy-based multimodal therapy (CBMMT).

Methods: A systematic review and meta-analysis of studies with data on LS-SCBC patients, involving both radical surgery and a bladder-preserving approach, were performed. PUBMED®, Embase® and Scopus® databases were searched for articles published before January 2024 according to the PRISMA statement. Eligible studies provided OS data for subgroups of LC-SCBC patients undergoing radical surgery or bladder-preserving approaches.

Results: From the identified 1,661 studies, our selection process identified five eligible publications comprising 1,041 patients for the meta-analysis. The pooled median OS for those who received RBMMT was 34.6 months (95% confidence interval (CI), 25.5-43.7), compared to 29.7 months (95% CI, 18.2-41.1) for those who received CBMMT.

Conclusions: This meta-analysis demonstrates an insignificant trend of better OS for RBMMT-treated over CBMMT-treated non-metastatic LS-SCBC patients, suggesting that an organ-preserving approach may provide similar or slightly better OS for well selected SCBC patients compared to the more radical CBMMT approach. This is a clinically meaningful result suggesting that the radical surgical approach - which is associated with a reduced quality-of-life - provides no survival benefit for LS-SCBC patients.

Funding: This work has been supported by the Ministry for Innovation and Technology from the source of the National Research Development and Innovation Fund (K139059).

University

Semmelweis University

Supervisor

Tibor Szarvas

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8006

Start

16:15

End

16:18