PhD Scientific Days 2024

Poster Session J - Pathological and Oncological Sciences 1.

Antiproliferative activities of cinchona alkaloid derivatives in EBC-1 cell line

Előadó neve

Dr. Takács, Angéla

Neptun code

C3XJ4U

Előadó munkahelye

Institute of Genetics, Cell- and Immunobiology

Előadó telefonszáma

06206701511

Előadó e-mail címe

angela.takacs1@gmail.com

Az előadás címe

Antiproliferative activities of cinchona alkaloid derivatives in EBC-1 cell line

Szerző(k) neve és munkahelye

Angéla Takács¹

1: Semmelweis Egyetem Genetikai, Sejt- és Immunbiológiai Intézet

Bemutatás módja

Poszter

Szekció

Poster Session J - Pathological and Oncological Sciences 1.

Language of the presentation

Hungarian

Preferred session

Pathological and Oncological Sciences

Összefoglaló szövege

Historically, extracts from the bark stem of Cinchona officinalis containing quinine and alkaloids have been utilized to treat fever and malaria. Recent research has uncovered apoptotic properties in cancer cells attributed to derivatives of cinchona alkaloids. Likewise, chalcones, plant-based polyphenolic compounds, are known for their anti-fungal, antimicrobial, antimalarial, and anticarcinogenic properties. In this study, we defined the cytotoxic and antiproliferative effects of synthetic hybrids combining cinchona and chalcone in human cancer cell lines. Specifically, two derivatives, AD-12 and AD-13, exhibited IC50 values below 2 µM in lung squamous cell carcinoma (EBC-1) cells. Our findings demonstrate that AD-12 and AD-13 increased intracellular ROS levels and induced caspase-3/7 and -8 activity in EBC-1 cells, leading to apoptosis. Furthermore, these apoptotic effects coincided with a temporary inhibition of P-gp efflux activity, while the expression levels of P-gp transporters remained constant. Collectively, our study highlights the promise of cinchona-chalcone hybrids as potential candidates for novel anticancer therapeutics.
Funding: ÚNKP-23-4-I-SE-6 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation fund and the National Competitiveness and Excellence Programme (NVKP_16-1-2016-0036)

University

Semmelweis University

Supervisor

Dr. Eszter Lajkó, Dr. László Kőhidai

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2925

Start

16:25

End

16:28