PhD Scientific Days 2024

Poster Session L - Health Sciences 1.

Changes in Body Composition Preceding the Diagnosis of Type-2 Diabetes Mellitus

Előadó neve

Dr. Major, David

Neptun code

EH55NI

Előadó munkahelye

Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University

Előadó telefonszáma

+36206701429

Előadó e-mail címe

major.david@semmelweis.hu

Az előadás címe

Changes in Body Composition Preceding the Diagnosis of Type-2 Diabetes Mellitus

Szerző(k) neve és munkahelye

David Major¹, Vince Fazekas-Pongor¹, Wei Yi Hung¹, Archana Singh-Manoux^2,3, Eric J. Brunner⁴, Mika Kivimäki^2,5, Adam G. Tabak^1,2,6

1: Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University
2: Brain Sciences, University College London, United Kingdom
3: Université de Paris, Inserm U1153, Epidemiology of Ageing & Neurodegenerative Diseases, Paris, France
4: Department of Epidemiology and Public Health, University College London, London, United Kingdom
5: Clinicum, Faculty of Medicine, University of Helsinki, Finland
6: Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session L - Health Sciences 1.

Language of the presentation

Hungarian

Preferred session

Health Sciences

Összefoglaló szövege

Introduction
Anthropometric and body composition measures are important predictors of type 2 diabetes mellitus (T2DM), yet their trajectories before diagnosis are underexplored.
Aims
Our study aimed to compare anthropometric (body mass index [BMI], waist circumference [WC]) and body composition (fat mass [FM], fat-free mass [FFM]) trajectories before the diagnosis T2DM to aging trajectories of individuals without T2DM during follow-up.
Method
Data from the Whitehall II study (prospective cohort of British civil servants) was used. 5-yearly BMI and WC were available from 1991 to 2011, while 5-yearly FM and FFM measures were available from 1997 to 2011. Linear mixed models with a backward timescale (from diagnosis or end of follow-up) were performed stratified by sex and adjusted for age, occupational grade, ethnicity, and lifestyle factors.
Results
The analysis included 1674/990 women (233/81 incident T2DM) and 3917/2710 men (479/217 incident T2DM) with 49.8[0.1]/60.9[0.1] (mean[SE]) years of age at baseline for anthropometric/body composition measures. All examined parameters were higher among individuals who developed T2DM compared to controls. In women, FM, BMI, and WC exhibited a quadratic trend, with a faster increase in incident cases (dBMI 0.04[0.01] kg/m2/year, dFM 0.19[0.09] kg/year, dWC 0.2[0.05] cm/year). Conversely, FFM decreased linearly in both groups, with similar rates of decline. In men, FM, BMI, and WC also followed a quadratic trajectory, with a faster rate of increase in incident cases compared to controls (dBMI 0.03 [0.01] kg/m2/year, dFM 0.23 [0.04] kg/year, dWC 0.08 [0.02] cm/year). FFM exhibited a quadratic decrease in both groups, with incident cases experiencing a slower rate of decline (0.06 [0.03] kg/year).
Conclusion
Elevated anthropometric and body composition measures were present in incident diabetic cases 10-20 years prior to diagnosis compared to controls. Incident cases exhibited accelerated increases in these measures, except for FFM, which declined during follow-up at comparable or slower rates compared to controls. Integration of body composition metrics into risk assessment tools could refine the accuracy of diabetes prediction.
Funding
Supported by the ÚNKP-23-3-II-SE-14 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Adam G. Tabak

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

3799

Start

16:25

End

16:28