PhD Scientific Days 2024

Poster Session H - Theoretical and Translational Medicine 1.

Fabrication of Polysuccinimide-Lidocaine meshes for enhanced postoperative pain relief

Előadó neve

Mr. Chrysanthou, Christodoulos

Neptun code

JBX8VQ

Előadó munkahelye

Semmelweis egyetem

Előadó telefonszáma

0036706042650

Előadó e-mail címe

chrischrys10@gmail.com

Az előadás címe

Fabrication of Polysuccinimide-Lidocaine meshes for enhanced postoperative pain relief

Szerző(k) neve és munkahelye

Christodoulos Chrysanthou¹

1: Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session H - Theoretical and Translational Medicine 1.

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: Managing post-operative pain is the cornerstone of Enhanced Recovery after Surgery (ERA). Although nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly utilized, their use is associated with heightened risks of nephrotoxicity and gastrointestinal complications. Similarly, opioids, while an option, entail numerous adverse effects including respiratory depression, nausea, vomiting, constipation, and urinary incontinence. Conversely, lidocaine has shown promise in alleviating early postoperative pain and enhancing recovery quality. However, its intramuscular administration typically provides relief for only up to 90 minutes. Introducing lidocaine-embedded meshes could potentially extend the drug's half-life post-surgery, thereby further enhancing recovery quality.

Objective: This study aimed to develop a fibrous mesh with specific chemical and physical attributes, offering a potential alternative for managing post-operative pain.

Materials and Methods: Polysuccinimide (PSI) was synthesized through thermal polycondensation of L-aspartic acid, following an established protocol. Mesh fabrication employed electrospinning, with subsequent assessments encompassing chemical composition, physical structure, and mechanical properties. Techniques utilized included ATR-FTIR spectroscopy, scanning electron microscopy, uniaxial mechanical testing and UV-Vis Spectroscopy.

Results: The fabrication of PSI meshes was successful, as confirmed by ATR-FTIR spectroscopy. Scanning electron microscopy revealed fiber dimensions averaging 450 nm ± 100 nm, indicative of appropriate mesh structure. Mechanical testing validated the suitability of the meshes for implantation.

Conclusion: The fabricated meshes exhibit properties conducive to implantation. Ongoing evaluation of the drug release profile via UV-Vis spectroscopy indicates promising outcomes. Future steps involve conducting in vitro cell studies and progressing to in vivo animal trials.

University

Semmelweis University

Supervisor

Dr. Konstantinos Voniatis

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8034

Start

15:10

End

15:13