PhD Scientific Days 2024

Pathological and Oncological Sciences II.

Malignant transformation and long-term outcome of oral and laryngeal leukoplakia

Előadó neve

Dr. Bukovszky, Botond

Neptun code

W659PV

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36303281455

Előadó e-mail címe

bukovszkybotond@gmail.com

Az előadás címe

Malignant transformation and long-term outcome of oral and laryngeal leukoplakia

Szerző(k) neve és munkahelye

Botond Bukovszky¹, János Fodor², Erika Tóth², Zsuzsa S Kocsis², Ferenc Oberna², Örs Ferenczi², Csaba Polgár²

1: Semmelweis University Faculty of Dentistry
2: National Institute of Oncology

Bemutatás módja

Szóbeli

Szekció

Pathological and Oncological Sciences II.

Language of the presentation

Hungarian

Preferred session

Pathological and Oncological Sciences

Összefoglaló szövege

Introduction
Oral or laryngeal leukoplakia has an increased risk for malignant transformation but the risk of the two anatomical sites has not been compared to each other yet.

Aims
To study the risk of malignant transformation of oral and laryngeal leukoplakia and to compare of the risk of the two anatomical sites.

Method
Clinical data of 253 patients with leukoplakia (oral = 221 or laryngeal = 32) enrolled from January 1996 to January 2022 were analyzed. One hundred and seventy underwent biopsy and 83 did not. The mean follow-up time was 148.8 months. Risk factors for the malignant transformation of leukoplakia were identified using Cox proportional hazard models.

Results
In the oral or laryngeal group, the rate of cancer was 21.7% and 50% (p = 0.002), respectively. The 10-year estimated malignant transformation was 15.1% and 42% (p < 0.0001), respectively. The laryngeal group had an increased risk of malignant transformation (p < 0.0001). The 5-year estimated survival with leukoplakia-associated cancer for the oral or laryngeal group was 40.9% and 61.1% (p = 0.337), respectively. Independent predictors of malignant transformation in the oral group were dysplasia and the grade of dysplasia of the leukoplakia, and in the laryngeal group, dysplasia had a significant impact. The malignant transformation rate was low for oral patients without biopsy or with no dysplasia, 3.9% and 5.1%, respectively. The malignant transformation occurred over 10 years.

Conclusion
Patients with dysplastic leukoplakia have an increased risk of malignant transformation, but the risk is higher with laryngeal than with oral leukoplakia. There is no significant difference between the groups regarding survival with leukoplakia-associated cancer. Oral patients with no dysplastic lesions have a low risk of malignant transformation. A complete excision and long-term follow up are suggested for high-risk patients to diagnose cancer in an early stage and to control late (over 10 years) malignant events.

Funding
Our study was not funded.

University

Semmelweis University

Supervisor

Prof. Dr. Polgár Csaba, Prof. Dr. Dobó-Nagy Csaba

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8070

Start

17:30

End

17:40