PhD Scientific Days 2024

Poster Session P - Conservative Medicine

Primary localized cutaneous amyloidosis: Diagnostic and therapeutic challenges of a rare cutaneous disease

Előadó neve

Dr. Pálla, Sára

Neptun code

P441QK

Előadó munkahelye

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University

Előadó telefonszáma

+36303632658

Előadó e-mail címe

sarazakarias@gmail.com

Az előadás címe

Primary localized cutaneous amyloidosis: Diagnostic and therapeutic challenges of a rare cutaneous disease

Szerző(k) neve és munkahelye

Sára Pálla¹, Enikő Kuroli², Eszter Alexa Tóth¹, Bernadett Hidvégi¹, Péter Holló¹, Márta Medvecz¹

1: Department of Dermatology, Venereology and Dermatooncology, Semmelweis University
2: Department of Pathology and Experimental Cancer Research, Semmelweis University; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session P - Conservative Medicine

Language of the presentation

Hungarian

Preferred session

Conservative Medicine

Összefoglaló szövege

Introduction
Primary localized cutaneous amyloidosis (PLCA) is a chronic dermatologic disease characterized by the deposition of amyloid proteins in the papillary dermis of the skin without systemic involvement. There are three subtypes of PLCA: macular amyloidosis (MA), lichen amyloidosis (LA), and nodular amyloidosis (NA).
Aims
The aim of this retrospective study was to analyze the epidemiology of PLCA and examine various treatment regimens for its management.
Method
In this retrospective study, we collected data of all PLCA cases diagnosed at the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University between 1 January 2004 and 1 September 2022. Distribution of symptoms, age, sex, comorbidities, skin phototype, disease duration, treatment modalities and response to therapy were assessed. Dermoscopic images of selected lesions were evaluated.
Results
A total of 41 patients diagnosed with PLCA were included in our study, mean age at diagnosis was 54.6 ± 15.2 years. 22 patients presented with MA, 18 patients with LA, and 1 with BA. The skin of 26 patients was classified as phototype III, and the skin of 3 other patients as phototype IV. MA lesions were commonly located on the back, followed by the abdomen and the legs. In LA, the most commonly affected regions were the lower extremities, followed by the back. The dermoscopic examination of MA showed white central structureless areas around the follicles, surrounded with brown and grey dots. In LA, structureless white areas were observed in a more irregular pattern, surrounded by brown and grey dots and globules.
Conclusion
We conducted a retrospective, monocentric study on the epidemiology of PLCA. The treatment regimens used in our center were also analyzed. Corticosteroids were the most frequently used treatment; however, the long-term efficacy regarding the symptomatic relief remains questionable. Given the rarity of this chronic cutaneous disease, further randomized controlled trials on newly available treatment options are needed to improve therapeutic possibilities. Further, guidelines for an evidence-based therapeutic regimen are also necessary.
Funding
This work was supported by grants from the Hungarian National Research, Development and Innovation Office – NKFIH grant [FK_131916, 2019], and EFOP- 3.6.3-VEKOP-16-2017-00009.

University

Semmelweis University

Supervisor

Márta Medvecz Dr.

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6856

Start

16:20

End

16:23